GEO DataSets

(Submitter supplied) Alzheimer's disease(AD) is a neurodegenerative disease with a long incubation period.Most of the constructed lncRNA-associated ceRNA regulatory networks are only based on the differences between clinical AD and control people or mice at a single time piont, the dynamic changes of these transcripts expression profiles with age from non-set to onset of AD need to be further elucidated.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL25663

27 Samples

Download data: TXT

(Submitter supplied) Fscn2-/- mouse is a typical model of age-related hearing loss which exhibits progressive hearing impairment and outer hair cell loss from 3 weeks of age. To investigate the molecular mechanism of hearing loss in Fscn2 knockout mice, gene expression profiling was performed on the inner ears for Fscn2+/+ and Fscn2-/- mice at 8 weeks of age using microarray analysis. Hearing screening tests at 8 weeks of age showed that the auditory brainstem response thresholds of Fscn2-/- mice were increased to 70-75 dB SPL at stimuli of click, while those of Fscn2+/+ mice were within the normal range(< 55 dB SPL). more...

Organism:

Mus musculus

Type:

Expression profiling by array; Non-coding RNA profiling by array

Platform:

GPL25663

6 Samples

Download data: TXT

(Submitter supplied) To present a potential therapeutic target for cardiac fibrotic remodeling in cardiovascular diseases

Organism:

Mus musculus

Type:

Expression profiling by array; Non-coding RNA profiling by array

Platform:

GPL25663

10 Samples

Download data: TXT

(Submitter supplied) Although ageing is usually regarded as a high risk of cancer, the relationship between ageing stromal microenvironment and spontaneous cancer initiation is poorly understood. In murine models of DSS-induced colitis and AOM/DSS-induced colitis-associated cancer (CAC), we found ageing significantly inhibit both intestinal wound healing and simultaneous CAC initiation. In young mice, through conditional lineage tracing, a novel and important source of fibroblasts transformed from intestinal smooth muscle cells (ISMCs) was identified during intestinal wound healing, which existed persistently in CAC. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL25663

18 Samples

Download data: TXT

(Submitter supplied) Echinococcus multilocularis (Em) infection and the growth and proliferation of its metacestode within the liver of hosts are related to complex host–parasite interactions at the molecular level. However, the profiles of long non-coding RNAs (lncRNAs) and mRNAs of mice in response to Em are poorly understood. In this study, we detected numerous differentially expressed lncRNAs (DELs) and mRNAs (DEMs) in the mouse liver at eight time points after Em infection. more...

Organism:

Mus musculus

Type:

Non-coding RNA profiling by array; Expression profiling by array

Platform:

GPL25663

64 Samples

Download data: TXT

(Submitter supplied) This study aims to compared RNA expression profiles between the skin tissues of IRF1 knockout (IRF-/-) mice and wild-type mice by microarray analysis. Male IRF1 knockout (IRF-/-) mice and wild-type mice (8 weeks old) were irradiated with a single 35-Gy dose of irradiation was administered to the treatment area at a rate of 750 cGy/min using a 6-MeV electron beam accelerator (Clinac 2100EX, Varian Medical Systems, Inc., CA). more...

Organism:

Mus musculus

Type:

Non-coding RNA profiling by array

Platform:

GPL25663

8 Samples

Download data: TXT

(Submitter supplied) Long noncoding RNAs (lncRNAs) have potential applications in clinical diagnosis and targeted cancer therapies. However, the expression profile of lncRNAs in colorectal cancer (CRC) initiation and progression is still unclear.In the present study, the expression profiles of lncRNAs and mRNAs were determined by microarray at specific tumor stages in an AOM/DSS-induced primary colon cancer model.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL25663

12 Samples

Download data: TXT