GPL26127[RGSE] - GEO DataSets

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Items: 2

Select item 2001541791.

Legionella pneumophila infection rewires the Acanthamoeba castellanii transcriptome, highlighting a class of sirtuin genes

(Submitter supplied) Through RNA-sequencing we compared A. castellanii infected with wild type L. pneumophila to A. castellanii infected with an isogenic dotA mutant strain, which is unable to replicate intracellularly. We identified clear morphological and transcriptional changes in A. castellanii over the course of infection. Genes differentially expressed during infection fell into fundamental biological processes, such as small GTPase signalling, cytoskeleton dynamics, metabolism and cell proliferation. more...

Organism:: Acanthamoeba castellanii

Type:: Expression profiling by high throughput sequencing

Platform:: GPL26127
36 Samples

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Accession:: GSE154179

ID:: 200154179

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Select item 2001258762.

Symbiont-mediated defense against Legionella pneumophila in amoebae

(Submitter supplied) Legionella pneumophila are important opportunistic pathogens for which environmental reservoirs such as protists are crucial for the infection of humans. Free-living amoebae are considered key hosts providing nutrients and shelter for highly efficient intracellular proliferation of L. pneumophila, which eventually leads to lysis of the amoeba host cell. Yet, the significance of other bacterial players for L. more...