GPL33428[RGSE] - GEO DataSets

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Items: 3

Select item 2002418701.

MERSCOPE profiling of non-aneurysmal and aneurysmal human ascending aorta

(Submitter supplied) Single-molecule level spatial distribution of MERFISH (Multiplexed error-robust fluorescence in situ hybridization) probes targeting 140 genes were analyzed on two control (non-aneurysmal) samples and three TAA samples with Thoracic aortic aneurysm (TAA).

Organism:: Homo sapiens; Mus musculus

Type:: Other

Platform:: GPL33428
5 Samples

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Accession:: GSE241870

ID:: 200241870

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Select item 2002332232.

spatial RNA-seq of SCG

(Submitter supplied) Disruption of the physiologic sleep-wake cycle and low melatonin levels frequently accompany cardiac disease, yet the underlying mechanism has remained enigmatic. Immunostaining of sympathetic axons in optically cleared pineal glands from humans and mice with cardiac disease revealed their substantial denervation compared to controls. Spatial, single-cell, nuclear, and bulk RNA sequencing traced this defect back to the superior cervical ganglia (SCG), which responded to cardiac disease with accumulation of inflammatory macrophages, fibrosis, and the selective loss of pineal gland-innervating neurons. more...