GPL6051[RGSE] - GEO DataSets

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Items: 3

Select item 2000306001.

Comparative Genomics Reveals New Molecular targets for Accelerated Improvement of Erythromycin-producing Strains

(Submitter supplied) Information about molecular mechanisms underlying improvement of antibiotic-producing microorganisms with traditional mutation and screening approach is largely missing. This information is essential to develop rational approaches to strain improvement. In this study by using comparative genomic analysis we have identified all genetic changes that have occurred during development of an erythromycin overproducer, which was obtained by the traditional mutate-and-screen method. more...

Organism:: Saccharopolyspora erythraea

Type:: Expression profiling by array

Platform:: GPL6051
22 Samples

Download data: CEL, CHP

Series

Accession:: GSE30600

ID:: 200030600

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000120172.

Phenotype and expression profile of S. erythraea rifampicin-resistant (rif) mutants affected in erythromycin production

(Submitter supplied) In this study we have used the rifampicin selection as a tool to genetically improve the erythromycin producer Saccharopolyspora erythraea. Two rifampicin-resistant (rif) mutants, rif1 and rif6, have been characterized in more detail. With respect to the parental strain NRRL2338, rif1 (harboring the missense S444F) exhibited higher respiratory performance and final erythromycin yields; in contrast, rif6 (harboring the missense Q426R) was slow-growing, developmental-defective and severely impaired in erythromycin production. more...

Organism:: Saccharopolyspora erythraea

Type:: Expression profiling by array

Platform:: GPL6051
12 Samples

Download data: CEL, XML

Series

Accession:: GSE12017

ID:: 200012017

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000094223.

Complete Gene Expression Profiling of Saccharopolyspora erythraea NRRL 2338

(Submitter supplied) A DNA microarray was designed and constructed using the genome sequence of Saccharopolyspora erythraea strain NRRL 2338. Following growth in liquid medium, we analysed the expression of 6494 ORFs along the time course. The results indicated that the 404 genes, whose expression significatively correlated with the time course, identify three distinct growth phases: a rapid growth until 32 h (phase A); a growth slowdown until 52 h (phase B); another rapid growth phase from 56 h to 72 h (phase C) before entering the stationary phase. more...