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Items: 1 to 20 of 137

1.

Comparative transcriptomic profiles in U-BIOPRED and Australian Newcastle severe asthma cohorts

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platforms:
GPL6104 GPL10558
117 Samples
Download data
Series
Accession:
GSE147881
ID:
200147881
2.

Comparative transcriptomic profiles in U-BIOPRED and Australian Newcastle severe asthma cohorts [sputum]

(Submitter supplied) Severe asthma is a heterogeneous disease. Transcriptomic analysis contributes to understanding the driver mechanisms necessary for developing new therapies. The aim of this study was to identify mechanistic pathways of severe asthma across two independent cohorts.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6104
44 Samples
Download data: TXT
Series
Accession:
GSE147880
ID:
200147880
3.

Genome-wide analysis of SHOX targets in NHDF cells expressing SHOX WT vs SHOX HM mutant

(Submitter supplied) To elucidate the underlying molecular mechanisms and to better understand the broad phenotypic spectrum of SHOX deficiency, we aimed to identify novel SHOX targets. We analyzed differentially expressed genes in SHOX-overexpressing human fibroblasts (NHDF)
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6104
6 Samples
Download data: IDAT, XLS
Series
Accession:
GSE169732
ID:
200169732
4.

Maastricht Human Plaque Study (MaasHPS)

(Submitter supplied) Microarray transcriptional profiling of carotid atherosclerotic plaques taken from symptomatic patients undergoing carotid endarterectomy surgery.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6104
43 Samples
Download data: TXT
Series
Accession:
GSE163154
ID:
200163154
5.

Design of an unbiased machine learning workflow to predict Multiple Sclerosis staging from blood transcriptome

(Submitter supplied) Construction of gene expression-based classifiers to predict the different Multiple Sclerosis stages from peripheral blood mononuclear cells (PBMC) transcriptome of MS patients and controls.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platforms:
GPL10558 GPL6104
336 Samples
Download data: TXT
Series
Accession:
GSE136411
ID:
200136411
6.

Genome-wide analysis of colorectal cancer gene expression by using primary tumors, normal colon and lymph nodes

(Submitter supplied) Analysis of the difference in gene expression between colorectal cancer samples and control samples
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6104
16 Samples
Download data: TXT
Series
Accession:
GSE141174
ID:
200141174
7.

Transcriptomic analysis of induced sputum samples in severe asthma

(Submitter supplied) Gene expression profiles were generated from induced sputum samples in asthma and healthy controls. The study identified differential gene expression and pathways in severe asthma.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6104
69 Samples
Download data: TXT
Series
Accession:
GSE137268
ID:
200137268
8.

Gene expression profiling of pre-operative mTOR inhibitor everolimus treatment in breast cancer

(Submitter supplied) There is growing evidence that uncontrolled activation of the PI3K/Akt/mTOR pathway contributes to the development and progression of breast cancer. Inhibition of this pathway has antitumour effects in preclinical studies and efficacy in combination with other agents in breast cancer patients. The aim of this study is to characterise the effects of pre-operative everolimus treatment in primary breast cancer patients and to identify potential molecular predictors of response. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6104
88 Samples
Download data: TXT
Series
Accession:
GSE119262
ID:
200119262
9.

Gene expression analysis in AML cells lines, AML primary blasts and in CD34+ normal progenitors after 6-hour exposure to HDACi

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platforms:
GPL6104 GPL6883
38 Samples
Download data
Series
Accession:
GSE55154
ID:
200055154
10.

Gene expression analysis in AML cell lines and in primary blasts of AML patients after 6 hours of HDACi treatment.

(Submitter supplied) AML cell lines (K562, U937 and NB4) were treated with MS27-275 (MS) and SAHA for 6 hours and the gene expression analysis revealed commonly regulated genes by the 2 HDACi. AML blasts were treated with SAHA for 6 hours and gene expression profiles were compared to commonly regulated genes by MS and SAHA in AML cell lines. The analysis revealed commonly regulated genes in these systems by SAHA.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6104
15 Samples
Download data: TXT
Series
Accession:
GSE54871
ID:
200054871
11.

Gene expression analysis in AML systems after 6 hours of HDACi treatments

(Submitter supplied) K562, U937 and NB4 AML cell lines were treated with 2 HDACi, MS-275 and SAHA, and gene expression profiles were analysed to 6-hours treatments. The analysis revealed commonly regulated genes in the 3 cell lines and by 2 HDACi.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6104
9 Samples
Download data: TXT
Series
Accession:
GSE54869
ID:
200054869
12.

Colon cancer

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platforms:
GPL6104 GPL10558
72 Samples
Download data
Series
Accession:
GSE74604
ID:
200074604
13.

30 paired normal and tumor colorectal samples

(Submitter supplied) Analysis of differentially regulated genes in patients normal and colorectal tumor samples. The aim of this study was to identify genes that were differentially up- or down-regulated in the tumor samples as compared to the normal colon tissue
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6104
60 Samples
Download data: TXT
Series
Accession:
GSE74602
ID:
200074602
14.

RPF-1 transcription factor coordinates expression of developmental genes in inducible HEK293/RPF-1 stable transfectants

(Submitter supplied) RPF-1, a transcription factors encoded by POU6F2 gene, appears to be expressed in the developing nervous system and embryonic kidney. We generated a stable HEK/RPF-1 transfectant expressing the protein in a tetracycline (Tet)-dependent induction and addressed the whole transcriptome regulated by RPF-1. We detected a gross alteration of gene expression that is consistent with its occupancy at proximal promoters, and gel retardation assay and promoter-reporter activity, addressing a few target genes, indicated a dependence by RPF-1 of transcriptional response. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6104
12 Samples
Download data: TXT
Series
Accession:
GSE55472
ID:
200055472
15.

Acquired resistance of Jurkat cells to TNF-related apoptosis-inducing ligand (TRAIL): a role for histone deacetylase inhibitors as powerful apoptosis sensitizer.

(Submitter supplied) Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been shown to be a potent inducer of apoptosis in various cancer cell lines and primary cancer cells. However, in clinical trials administration of recombinant TRAIL or TRAIL death receptor agonists did not show sufficient efficacy for treatment of tested malignant disorders compared to standard chemotherapy. Acquired resistance of cancer cells to TRAIL and to other “death receptor” ligands may explain not only the inability of TRAIL and TRAIL “death receptor” agonists to achieve the clearance of cancer cells in vivo but also the escape of cancer cells from immune cell – mediated killing. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6104
8 Samples
Download data: TXT
Series
Accession:
GSE38745
ID:
200038745
16.

Acquired resistance of Jurkat cells to TNF-related apoptosis-inducing ligand (TRAIL)

(Submitter supplied) Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been shown to be a potent inducer of apoptosis in various cancer cell lines and primary cancer cells. However, in clinical trials administration of recombinant TRAIL or TRAIL death receptor agonists did not show sufficient efficacy for treatment of tested malignant disorders compared to standard chemotherapy. Acquired resistance of cancer cells to TRAIL and to other “death receptor” ligands may explain not only the inability of TRAIL and TRAIL “death receptor” agonists to achieve the clearance of cancer cells in vivo but also the escape of cancer cells from immune cell – mediated killing. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6104
8 Samples
Download data: TXT
Series
Accession:
GSE38743
ID:
200038743
17.

MDAH-041 Spontaneous Immortalization

(Submitter supplied) Gene expression at various stages of immortalization
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6104
16 Samples
Download data: TXT
Series
Accession:
GSE46931
ID:
200046931
18.

Systemic inflammation is associated with differential gene expression and airway neutrophilia in asthma

(Submitter supplied) Systemic inflammation is reported to be associated with neutrophilic airway inflammation in asthma, this study aimed to examine the molecular mechanisms of the neutrophilia that is associated with systemic inflammation, and hypothesized that asthma patients with systemic inflammation have a group of genes that are differentially expressed and are assciated with airway inflammation.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6104
50 Samples
Download data: TXT
Series
Accession:
GSE43397
ID:
200043397
19.

Human umbilical cord matrix mesenchymal stem cells suppress the growth of breast cancer by expression of tumor suppressor genes

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Rattus norvegicus; Homo sapiens
Type:
Expression profiling by array
Platforms:
GPL6104 GPL17223
12 Samples
Download data
Series
Accession:
GSE64839
ID:
200064839
20.

Human umbilical cord matrix mesenchymal stem cells suppress the growth of breast cancer by expression of tumor suppressor genes [human]

(Submitter supplied) Human and rat umbilical cord matrix mesenchymal stem cells (UCMSC) possess the ability to control the growth of breast carcinoma cells. Comparative analyses of two types of UCMSC suggest that rat UCMSC-dependent growth regulation is significantly stronger than that of human UCMSC. Their different tumoricidal abilities were clarified by analyzing gene expression profiles in the two types of UCMSC. Microarray analysis revealed differential gene expression between untreated naïve UCMSC and those co-cultured with species-matched breast carcinoma cells. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6104
6 Samples
Download data: TXT
Series
Accession:
GSE64827
ID:
200064827
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