GEO DataSets

(Submitter supplied) Using magneto-nanofection, iPS cells were efficiently generated by the transient expression of iPS genes in MEF (mouse embryonic fibroblast), suggesting that the non-viral magneto-nanofection method can be used for the efficient generation of iPS cells.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6481

10 Samples

Download data: TXT

(Submitter supplied) Illumina Beadchip array analyses of mouse embryonic stem cell gene expression profiles upon knockdown of Prmt6 vs GFP control.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6481

6 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens; Mus musculus

Type:

Expression profiling by array

Platforms:

GPL6947 GPL6481 GPL10558

31 Samples

Download data

(Submitter supplied) Pancreatic Gene Expression from Wild-Type, Stat1-Transgenic, and Stat1-CC-Transgenic Mice. This data was part of the set of data utilized to identify PARP9/DTX3L as a novel antiviral gene. Keywords: transgene state analysis

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6481

9 Samples

Download data: TXT

(Submitter supplied) Analysis of differential gene expression in chondrocytes due to S1P ablation in mice. The hypothesis tested in this study was that ablation of S1P in mice would result in differential gene expression in chondrocytes that may be responsible for the S1Pcko phenotype.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6481

12 Samples

Download data: TXT

(Submitter supplied) The brain is a functionally complex organ, the patterning and development of which are key to adult health. To help elucidate the genetic networks underlying mammalian brain patterning we conducted detailed transcriptional profiling during embryonic development of the mouse brain. 2400 genes were identified as showing differential expression between three developmental stages. Analysis of the data identified nine gene clusters to demonstrate analogous expression profiles. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6481

24 Samples

Download data: TXT

(Submitter supplied) Analysis of changes in gene expression after incubation of dendritic cells with immune complexes or medium. Since the dendritic cells are derived from three different mouse strains, either wild type, Fcγ receptor IIb KO (expresses only activating Fcγ receptors) or Fc receptor γ chain KO (expresses only inhibitory Fcγ receptor), the analysis gives important insight into the roles of the activating versus inhibiting Fcγ receptors on dendritic cells.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6481

24 Samples

Download data: TXT

(Submitter supplied) We analyzed gene expression profiling by an bioinformatic approach to identify the stage-specific gene sets associated with neural differentiation of mESCs. We exposed mESCs (B6G-2 cells) to titrated doses of retinoic acid (RA) for 4 days during embryoid body formation and then performed morphological analysis on day of differentiation (DoD) 8 and 29, or genomic microarray analysis on DoD 0, 2, 8 and 29. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6481

9 Samples

Download data: TXT

(Submitter supplied) Analysis of differences in gene expression in the mouse uterus during decidualization in the presence and absence of a conceptus. A deciduomal model previously shown to better mimick natural decidualization was used. The results reveal some, but very few, genes that are differentially expressed, which is unlike previous reports using other deciduomal models shown previously to not mimick natural decidualization.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6481

6 Samples

Download data: TXT

(Submitter supplied) Rhabdomyosarcomas (RSCs) are skeletal muscle neoplasms found in humans and domestic mammals. The A/J inbred strain developed a high frequency of RSC by 20 months of age while BALB/cJ and BALB/cByJ also develop RSC but less frequently. These neoplasms affected skeletal muscle surrounding either the axial or proximal appendicular skeleton and were characterized by pleomorphic cells with abundant eosinophilic cytoplasm, multiple nuclei, and cross striations that invaded locally. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS5527

Platform:

GPL6481

12 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus

Type:

Expression profiling by array

Datasets:

GDS4001 GDS4002

Platforms:

GPL6481 GPL7467

148 Samples

Download data: TXT

(Submitter supplied) Investigating the molecular basis and correlates of anxiety-related and depression-like behaviors, we generated a mouse model consisting of high (HAB), normal (NAB) and low (LAB) anxiety-related behavior mice. We utilized the elevated plus-maze for testing the genetic predisposition to anxiety-related behavior and, consequently, used this as selection criterion for the inbreeding of our animals. In depression-related tests, HAB mice display a more passive, depression-like coping strategy than LAB mice, resembling clinical comorbidity of anxiety and depression as observed in psychiatric patients. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6481

78 Samples

Download data: TXT

(Submitter supplied) We measured gene expression differences in the extensor digitorum longus (edl) skeletal muscle between wild-type and mice lacking Cu, Zn-superoxide dismutase to determine the effect of chronic oxidative stress on skeletal muscle.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6481

8 Samples

Download data: TXT

(Submitter supplied) The embryonic stem (ES) cell transcriptional and epigenetic networks are critical for the maintenance of ES cell self-renewal. It remains unclear whether interactions. Here we show that a core member of the Set/MLL complex, WDrepeat protein-5 (Wdr5), is a novel regulator of self-renewal and partners with Oct4 to maintain an intact transcriptional network and for efficient formation of induced pluripotent stem (iPS) cells. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platforms:

GPL6885 GPL6481

9 Samples

Download data: TXT

(Submitter supplied) To investigate the role of Aire in thymic selection, we examined the cellular requirements for generation of ovalbumin (OVA)-specific CD4 and CD8 T cells in mice expressing OVA under the control of the rat insulin promoter (RIP). Aire-deficiency reduced the number of mature single positive (SP) OVA-specific CD4+ or CD8+ T cells in the thymus, independent of OVA expression. Importantly, it also contributed in two way to OVA-dependent negative selection depending on the T cell type. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6481

6 Samples

Download data: TXT

(Submitter supplied) Comparison of gene expression differences between Dnmt3L heterozygous and wildtype pachytene spermatocytes, and similarly between Dnmt3L heterozygous and wildtype round spermatids which were isolated from the Dnmt3L knockout mouse line. This array was conducted to address the hypothesis that Dnmt3L heterozygosity results in deregulated gene expression within spermatocytes and spermatids. Results show that Dnmt3L heterozygosity causes numerous genes to be differentially regulated on a genome-wide level, showing that DNMT3L has an important role in regulating gene expression within these male germ cells.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6481

11 Samples

Download data: TXT

(Submitter supplied) Oculopharyngeal muscular dystrophy (OPMD) is an adult-onset disorder characterized by ptosis, dysphagia and proximal limb weakness. Autosomal-dominant OPMD is caused by a short (GCG)8–13 expansions within the first exon of the poly(A)-binding protein nuclear 1 gene (PABPN1), leading to an expanded polyalanine tract in the mutated protein. Expanded PABPN1 forms insoluble aggregates in the nuclei of skeletal muscle fibres. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6481

33 Samples

Download data: TXT

(Submitter supplied) K-ras mutations are observed in around 40% human colorectal adenomas and carcinomas and contribute to the pathogenesis of human and rodent colorectal tumour formation. Previously, we developed and characterised a strain of transgenic mice with inducible intestinal epithelial expression of K-rasVal12 via a Cre/LoxP system. To evaluate the influence of mutant K-ras on carcinogen-induced colorectal tumourigenesis, we induced neoplastic alterations in the large intestines of wild-type and K-rasVal12 mice using the colon-selective carcinogen 1, 2-dimethylhydrazine (DMH), which has been widely used to study chemically induced colorectal tumours that are histopathologically similar to those observed in humans. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6481

7 Samples

Download data: TXT

(Submitter supplied) BACKGROUND: The transcript levels of many genes exhibit significant variation in tissue samples from inbred laboratory mice. A microarray experiment was designed to separate transcript abundance variation across samples from adipose, heart, kidney, and liver tissues of C57BL/6J mice into within-mouse and between-mouse components. Within-mouse variance captures variation due to heterogeneity of gene expression within tissues, RNA-extraction, and array processing. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platforms:

GPL6481 GPL6246

120 Samples

Download data: CEL, TXT

(Submitter supplied) Niemann-Pick Type C disease is an autosomal recessive neurodegenerative disorder with abnormal lipid storage as the major cellular pathologic hallmark. Genetic analyses have identified mutations in NPC1 gene in the great majority of cases, while mutations in NPC2 account for the remainders. Yet, little is known regarding the cellular mechanisms responsible for NPC pathogenesis, especially for neurodegeneration, which is the usual cause of death. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platforms:

GPL6481 GPL4134

16 Samples

Download data: TXT