GEO DataSets

(Submitter supplied) Acute myeloid leukemia (AML) is a heterogeneous group of diseases. Normal cytogenetics (CN) constitutes the single largest group, while trisomy 8 (+8) as a sole abnormality is the most frequent trisomy. How trisomy contributes to tumorigenesis is unknown. We used oligonucleotide-based DNA microarrays to study global gene expression in AML+8 patients with +8 as the sole chromosomal abnormality and AML-CN patients. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL80

31 Samples

Download data: CEL

(Submitter supplied) Astrocytomas are heterogeneous intracranial glial neoplasms ranging from the highly aggressive malignant glioblastoma multiforme (GBM) to the indolent, low-grade pilocytic astrocytoma. We have investigated whether DNA microarrays can identify gene expression differences between high-grade and low-grade glial tumors. We compared the transcriptional profile of 45 astrocytic tumors including 21 GBMs and 19 pilocytic astrocytomas using oligonucleotide-based microarrays. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL80

51 Samples

Download data: CEL, TXT

(Submitter supplied) Embryonal tumours of the central nervous system (CNS) represent a heterogeneous group of tumours about which little is known biologically, and whose diagnosis, on the basis of morphologic appearance alone, is controversial. Medulloblastomas, for example, are the most common malignant brain tumour of childhood, but their pathogenesis is unknown, their relationship to other embryonal CNS tumours is debated, and patients' response to therapy is difficult to predict. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL80

100 Samples

Download data: CEL

(Submitter supplied) In an effort to develop a genomics-based approach to the prediction of drug response, we have developed an algorithm for classification of cell line chemosensitivity based on gene expression profiles alone. Using oligonucleotide microarrays, the expression levels of 6,817 genes were measured in a panel of 60 human cancer cell lines (the NCI-60) for which the chemosensitivity profiles of thousands of chemical compounds have been determined. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL80

60 Samples

Download data: CEL

(Submitter supplied) The optimal treatment of patients with cancer depends on establishing accurate diagnoses by using a complex combination of clinical and histopathological data. In some instances, this task is difficult or impossible because of atypical clinical presentation or histopathology. To determine whether the diagnosis of multiple common adult malignancies could be achieved purely by molecular classification, we subjected 218 tumor samples, spanning 14 common tumor types, and 90 normal tissue samples to oligonucleotide microarray gene expression analysis. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL98 GPL80

539 Samples

Download data: CEL, CHP, RPT, TXT

(Submitter supplied) Diffuse large B-cell lymphoma (DLBCL), the most common lymphoid malignancy in adults, is curable in less than 50% of patients. Prognostic models based on pre-treatment characteristics, such as the International Prognostic Index (IPI), are currently used to predict outcome in DLBCL. However, clinical outcome models identify neither the molecular basis of clinical heterogeneity, nor specific therapeutic targets. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL80

77 Samples

Download data: CEL, CHP, RPT, TXT

(Submitter supplied) Biologically and clinically meaningful tumor classification schemes have long been sought. Some malignant epithelial neoplasms, such as those in the thyroid and endometrium, exhibit more than one pattern of differentiation, each associated with distinctive clinical features and treatments. In other tissues, all carcinomas, regardless of morphological type, are treated as though they represent a single disease. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL80

113 Samples

Download data: CEL, TXT

(Submitter supplied) Histopathology is insufficient to predict disease progression and clinical outcome in lung adenocarcinoma. Here we show that gene-expression profiles based on microarray analysis can be used to predict patient survival in early-stage lung adenocarcinomas. Genes most related to survival were identified with univariate Cox analysis. Using either two equivalent but independent training and testing sets, or 'leave-one-out' cross-validation analysis with all tumors, a risk index based on the top 50 genes identified low-risk and high-risk stage I lung adenocarcinomas, which differed significantly with respect to survival. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL80

96 Samples

Download data: CEL, TXT

(Submitter supplied) Rhinovirus (RV) infection has been shown to exacerbate asthma. Understanding of the underlying mechanisms by which RV infections provoke airway inflammation and remodeling in asthma may offer significant insight into asthma pathogenesis and exacerbations as well as offer opportunities for improved disease management. Expression analysis of RV A16-treated primary peripheral blood monocytes from human donors was performed to determine what pattern of gene expression is associated with RV infection of monocytes in vitro.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL80

2 Samples

Download data: CEL

(Submitter supplied) We hypothesized that the transcriptome of primary cultures of morphologically normal ovarian surface epithelial cells could be altered by the presence of a heterozygous BRCA1 or BRCA2 mutation. We aimed to discover early events associated to ovarian carcinogenesis, which could represent putative targets for preventive strategies of this silent killer tumor. We identified the first molecular signature associated with French Canadian BRCA1 or BRCA2 founder mutations in morphologically normal ovarian epithelial cells. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL80

13 Samples

Download data: CEL

(Submitter supplied) Epithelial cells of the intestine respond to IFN-gamma, which is a critical regulator of the inflammatory response. Here we sought to determine the impact that this cytokine has on epithelial cell gene expression in an in vitro inflammation model.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL80

5 Samples

Download data: TXT

(Submitter supplied) The objective of this study was to gain insights into the biological basis of colon cancer progression by characterizing gene expression differences between normal colon epithelium, corresponding colorectal primary tumors and metastases. We found a close similarity in gene expression patterns between primary tumors and metastases, indicating a correlation between gene expression and morphological characteristics. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL80

32 Samples

Download data: CEL

(Submitter supplied) Type 2 diabetes mellitus (DM) is characterized by insulin resistance and pancreatic beta-cell dysfunction. In high-risk subjects, the earliest detectable abnormality is insulin resistance in skeletal muscle. Impaired insulin-mediated signaling, gene expression, and glycogen synthesis, and accumulation of intramyocellular triglycerides have all been linked with insulin resistance, but no specific defect responsible for insulin resistance and DM has been identified in humans. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL80

20 Samples

Download data: CEL

(Submitter supplied) mRNA assays were performed on 51 samples of human colorectal tumors using Affymetrix HuGeneFL arrays containing 7129 probe-sets. We compared 38 microsatelite stable (MSS) tumors with 13 microsatellite instable-high (MSI) tumors to form a list of genes differing between the two types. In order to identify molecular signatures characterizing MSI tumors, we examined only MSI-high cancers and not MSI-low ones. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL80

51 Samples

Download data: CEL, XLS

(Submitter supplied) Smokers weigh less and have less body fat than non-smokers, and increased body fat and weight gain are observed following smoking cessation. To assess a possible molecular mechanism underlying the inverse association between smoking and body weight, we hypothesized that smoking may induce the expression of a fat depleting gene in the airway epithelium, the cell population that takes the brunt of the stress of cigarette smoke. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL80 GPL570 GPL96

92 Samples

Download data: CEL, CHP

(Submitter supplied) To determine if differences in the severity of pulmonary infection in cystic fibrosis been seen in late isolates od Pseudomonas aeruginosa and Burkholderia cepacia are associated with differences in the initial repsonse of alveolar macrophages (AM) to these pathogens, we assessed gene expression changes in human AM in response to infection with a laboratoty strain, early and late clinical isolates of P. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL80

28 Samples

Download data: CEL

(Submitter supplied) Plexiform leiomyomata are a histologically defined subgroup of benign uterine smooth muscle tumors based on their epitheliod cytology and abundant extracellular matrix. We used microarrays to compare plexiform leiomyomata to normal myometrium (smooth muscle of the uterine wall), typical leiomyomata, cellular or atypical leiomyomata and malignant leiomyosarcoma of the uterus. Keywords: tumor analysis

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL80 GPL570

30 Samples

Download data: CEL, EXP

(Submitter supplied) We have previously described differences in the expression profiles of tumors by comparing tumors of two known classes: low malignant potential versus highly malignant (invasive). This report presents an effort to discover unknown classes within a large heterogeneous set of ovarian tumors, using unsupervised learning approaches. We were able to define four classes in a set of 74 ovarian cancer tumors. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL80

74 Samples

Download data: CEL

(Submitter supplied) To identify insulin responsive genes in humans, in the first protocol, skeletal muscle biopsies from six non-diabetic subjects were obtained before and after a two-hour of hyperinsulinaemic (infusion rate 40 mU/m2/min) euglycemic clamp. A variable infusion of glucose (180 g/l) enriched with tritiated glucose (100 μCi/500 ml) maintained euglycemia during insulin infusion, with monitoring of plasma glucose concentration every 5 to 10 min during the basal and clamp periods using an automated glucose oxidation method (Glucose Analyzer 2, Beckman Instruments, Fullerton, CA). more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Datasets:

GDS2790 GDS2791

Platforms:

GPL80 GPL96

24 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL96 GPL80 GPL570

124 Samples

Download data: CEL, CHP, EXP