GPL8490[RGSE] - GEO DataSets

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Select item 2001672901.

Epigenome analysis of parent and radioresistant oral cancer cells ( OCSL).

(Submitter supplied) Genome wide DNA methylation profiling changes in parent and radioresistant oral cancer cells ( OCSL-P and OCSL-R ) by The Illumina Infinium WG Methylation27.

Organism:: Homo sapiens

Type:: Methylation profiling by genome tiling array

Platform:: GPL8490
2 Samples

Download data: TXT

Series

Accession:: GSE167290

ID:: 200167290

Analyze with GEO2R

Select item 2001655842.

Epigenome analysis of parent and radioresistant OSCC cells(OML1 and OML1R ).

(Submitter supplied) Genome wide DNA methylation profiling changes in parent and radioresistant OSCC cells (OML1 and OML1R ) by The Illumina Infinium WG Methylation27.

Organism:: Homo sapiens

Type:: Methylation profiling by array

Platform:: GPL8490
4 Samples

Download data: TXT

Series

Accession:: GSE165584

ID:: 200165584

Analyze with GEO2R

Select item 2001141313.

Germline Copy Number Variants are Associated with Methylation Variation in the Genome

(Submitter supplied) Illumina methylation 27 array (Illumina) analysis was performed on 24 HapMap individuals including one CEU trio (family 1463 including NA12878, NA12891, NA12892) and one YRI trio (family Y117 including NA19240, NA19238, NA19239)

Organism:: Homo sapiens

Type:: Methylation profiling by array

Platform:: GPL8490
24 Samples

Download data: IDAT, TXT

Series

Accession:: GSE114131

ID:: 200114131

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000985344.

DNA methylation instability by BRAF-mediated TET silencing and lifestyle-exposure divides colon cancer pathways

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens; Mus musculus

Type:: Methylation profiling by genome tiling array; Methylation profiling by array

4 related Platforms
33 Samples

Download data: IDAT, PAIR

Series

Accession:: GSE98534

ID:: 200098534

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000985315.

DNA methylation instability by BRAF-mediated TET silencing and lifestyle-exposure divides colon cancer pathways [tumor, paired normal]

(Submitter supplied) Promoter hypermethylation divides colon cancers into subtypes with and without a CpG island methylator phenotype (CIMP). Here, we performed genome-wide DNA methylation profiling of colonic normal and tumor tissues to dissect development of CpG hypermethylation in colon carcinogenesis. This identified age-environment related versus genetically driven CpG hypermethylation, the latter being associated with CIMP cancers. more...

Organism:: Homo sapiens

Type:: Methylation profiling by genome tiling array; Methylation profiling by array

Platform:: GPL8490
16 Samples

Download data: TXT

Series

Accession:: GSE98531

ID:: 200098531

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001390326.

DNA methylation profiling of lung adenocarcinomas and patient-matched non-malignant lung

(Submitter supplied) Gene function in cancer is often cell type-specific. The epithelial cell-specific transcription factor ELF3 is a documented tumour suppressor in many epithelial tumours yet displays oncogenic properties in others. Here, we show that ELF3 is an oncogene in the adenocarcinoma subtype of lung cancer (LUAD), providing genetic, functional, and clinical evidence of subtype specificity. We discover a region of focal amplification at chromosome 1q32.1 encompassing the ELF3 locus in LUAD which is absent in the squamous subtype. more...

Organism:: Homo sapiens

Type:: Methylation profiling by array

Platform:: GPL8490
154 Samples

Download data: TXT

Series

Accession:: GSE139032

ID:: 200139032

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001374817.

Epithelial Tumour Suppressor ELF3 is a Lineage-Specific Amplified Oncogene in Lung Adenocarcinoma

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Methylation profiling by array; Genome variation profiling by SNP array

Platforms:: GPL16686 GPL8490 GPL6801
326 Samples

Download data: CEL, CHP

Series

Accession:: GSE137481

ID:: 200137481

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000378728.

Epigenome analysis to identify DNA methylation changes associated with colorectal carcinogenesis

(Submitter supplied) DNA methylation profiling of matched primary tumor (CRC), cancer-associated mucosa (CAM) and blood from two colorectal cancer patients to identify cancer-specific methylation targets.

Organism:: Homo sapiens

Type:: Methylation profiling by array

Platform:: GPL8490
18 Samples

Download data: TXT

Series

Accession:: GSE37872

ID:: 200037872

Analyze with GEO2R

Select item 2001203429.

Aberrant transcriptomes and DNA methylomes define pathways that drive pathogenesis and loss of brain laterality/asymmetry in schizophrenia and bipolar disorder

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platforms:: GPL8490 GPL16311
41 Samples

Download data: CEL, IDAT

Series

Accession:: GSE120342

ID:: 200120342

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20012034110.

Aberrant transcriptomes and DNA methylomes define pathways that drive pathogenesis and loss of brain laterality/asymmetry in schizophrenia and bipolar disorder [Illumina]

(Submitter supplied) Although the loss or reversal of brain laterality is one of the most consistent modalities in schizophrenia (SCZ) and bipolar disorder (BD), its molecular basis remains elusive. Our limited previous studies indicated that epigenetic modifications are key to the asymmetric transcriptomes of brain hemispheres. We used whole-genome expression microarrays to profile post-mortem brain samples from subjects with SCZ, psychotic BD [BD(+)] or non-psychotic BD [BD(-)], or matched controls (n=10/group, corresponding to different brain hemispheres) and performed whole-genome DNA methylation (DNAM) profiling of the same samples (n=3-4/group) to identify pathways associated with SCZ or BD(+) and genes/sites susceptible to epigenetic regulation. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL8490
11 Samples

Download data: IDAT

Series

Accession:: GSE120341

ID:: 200120341

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20011887211.

Methylation profile of ewing sarcoma cell lines

(Submitter supplied) Study of promoter methylation of ewing sarcoma cell lines and mesenchymal stem cell from ewing sarcoma patients and healthy donors

Organism:: Homo sapiens

Type:: Methylation profiling by array

Platform:: GPL8490
24 Samples

Download data: IDAT

Series

Accession:: GSE118872

ID:: 200118872

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20006837212.

Profiles of 20 paired (normal and varicose) vein samples from the patients with varicose vein disease

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Methylation profiling by genome tiling array

Platforms:: GPL6883 GPL8490
34 Samples

Download data: IDAT

Series

Accession:: GSE68372

ID:: 200068372

Select item 20006831913.

Genome-wide DNA methylation profiles of 20 paired (normal and varicose) vein samples from the patients with varicose vein disease.

(Submitter supplied) To identify genes involved in the formation of a pathological phenotype of varicose veins, we attempted to analyze the methylome of their constituent cells and compare it to the methylome of normal veins from the same patient. We identified a number of genes of extracellular matrix remodeling and cell-cell communication whose methylation status was significantly changed in disease condition.

Organism:: Homo sapiens

Type:: Methylation profiling by genome tiling array

Platform:: GPL8490
20 Samples

Download data: IDAT, TXT

Series

Accession:: GSE68319

ID:: 200068319

Select item 20004326514.

An epigenetic panel of NEFH and HS3ST2 relates to overall survival in human ovarian cancer .

(Submitter supplied) We used methylation DNA arrays to observe the genomic wild methylation profiles in 31 malignant ovarian tumors. After validations, we selected, NEFH and HS3ST2. We used bisulfite pyrosequencing to expose methylation status for 84 independent samples. Kaplan–Meier survival and Cox regression analysis estimates the association with ovarian cancer outcome. We discovered patients with high methyatlion of two genes, had a shorter median 5-years overall survival. more...

Organism:: Homo sapiens

Type:: Methylation profiling by array

Platform:: GPL8490
31 Samples

Download data: TXT

Series

Accession:: GSE43265

ID:: 200043265

Select item 20005730015.

Blood samples as a surrogate of brain methylation

(Submitter supplied) Epigenomic landscapes are variable between cells and tissue types and, fluctuate in time according to a number of factors such as the age related, environmental or nutritional factors among others. Existing biobanks that archive longitudinally assessed and correctly phenotyped samples have not stored exposure-disease relevant target tissue but DNA from peripheral sources such as the whole blood or buccal cells. more...

Organism:: Homo sapiens

Type:: Genome variation profiling by SNP array

Platform:: GPL8490
46 Samples

Download data: TXT

Series

Accession:: GSE57300

ID:: 200057300

Select item 20008179816.

Potential roles of DNA methylation in the initiation and establishment of replicative senescence revealed by array-based methylome and transcriptome analyses

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Methylation profiling by array

Platforms:: GPL17077 GPL13534 GPL8490
16 Samples

Download data: TXT

Series

Accession:: GSE81798

ID:: 200081798

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20008178817.

Potential roles of DNA methylation in the initiation and establishment of replicative senescence revealed by array-based methylome and transcriptome analyses [methylation]

(Submitter supplied) Cellular senescence is classified into two types; replicative and premature senescence. Gene expression and epigenetic changes are different in types of senescence, replicative and premature senescence, and cell types. Normal human diploid fibroblast TIG-3 cells were often used in cellular senescence research, however, their epigenetic profiles were not fully understood. To elucidate how cellular senescence is epigenetically regulated in TIG-3 cells, we analyzed gene expression and DNA methylation profiles among three types of senescent cells, namely, replicative senescent, RAS-induced senescent (RIS) and non-permissive temperature-induced senescent SVts8 cells, using gene expression and methylation microarrays. more...

Organism:: Homo sapiens

Type:: Methylation profiling by array

Platform:: GPL8490
8 Samples

Download data: TXT

Series

Accession:: GSE81788

ID:: 200081788

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20008384518.

Methylation profiles of lung adenocarcinoma patients in Taiwan

(Submitter supplied) Genome wide DNA methylation profiling of tumor samples with lung adenocarcinoma patients. The Illumina HumanMethylation27 BeadChip array was used to obtain DNA methylation profiles across approximately 27,578 CpGs in lung cancer samples. Samples included tumor samples with lung adenocarcinoma.

Organism:: Homo sapiens

Type:: Methylation profiling by array; Methylation profiling by genome tiling array

Platform:: GPL8490
39 Samples

Download data: TXT

Series

Accession:: GSE83845

ID:: 200083845

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20002488419.

Methylation RIKEN-cohort

(Submitter supplied) BACKGROUND: Obesity is associated with changes in fat cell gene expression and metabolism. What drives these changes is not well understood. We aimed to explore fat cell epigenetics, i.e., DNA methylation, as one mediator of gene regulation, in obese women. The global DNA methylome for abdominal subcutaneous fat cells was compared between 15 obese case (BMI 41.4?±?4.4 kg/m(2), mean?±?SD) and 14 never-obese control women (BMI 25.2?±?2.5 kg/m(2)). more...