GSE100376[Accession] - GEO DataSets - NCBI

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Select item 2001003761.

HIV-1 infection of human monocyte-derived dendritic cells with and without the integrase inhibitor, Raltegravir (ATAC-Seq).

(Submitter supplied) Myeloid dendritic cells (DCs) have the innate capacity to sense pathogens and orchestrate immune responses. However, DCs do not mount efficient immune responses to HIV-1, due to potent restriction at the level of reverse transcription. Here, we uncover that when reverse transcription is allowed to proceed, DCs detect HIV-1 in distinct phases, before and after integration. Blocking integration suppressed, but did not abolish, activation of the transcription factor, IRF3, interferon responses, and DC maturation. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL18573
24 Samples

Download data: BW

Series

Accession:: GSE100376

ID:: 200100376

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 1000185732.

Illumina NextSeq 500 (Homo sapiens)

Organism:: Homo sapiens

12651 Series
344593 Samples

Platform

Accession:: GPL18573

ID:: 100018573

Select item 3026797603.

HIV_RAL_48h_D225

Organism:: Homo sapiens

Source name:: monocyte derived dendritic cells infected with HIV in the presence of Vpx, time (hours): 48, drug: Raltegravir, donor: D225

Platform:: GPL18573
Series:: GSE100376 GSE100377

Download data: BW

Sample

Accession:: GSM2679760

ID:: 302679760

SRA Run Selector

Select item 3026797594.

HIV_RAL_32h_D225

Organism:: Homo sapiens

Source name:: monocyte derived dendritic cells infected with HIV in the presence of Vpx, time (hours): 32, drug: Raltegravir, donor: D225

Platform:: GPL18573
Series:: GSE100376 GSE100377

Download data: BW

Sample

Accession:: GSM2679759

ID:: 302679759

SRA Run Selector

Select item 3026797585.

HIV_RAL_16h_D225

Organism:: Homo sapiens

Source name:: monocyte derived dendritic cells infected with HIV in the presence of Vpx, time (hours): 16, drug: Raltegravir, donor: D225

Platform:: GPL18573
Series:: GSE100376 GSE100377

Download data: BW

Sample

Accession:: GSM2679758

ID:: 302679758

SRA Run Selector

Select item 3026797576.

Organism:: Homo sapiens

Source name:: monocyte derived dendritic cells infected with HIV in the presence of Vpx, time (hours): 0, drug: Raltegravir, donor: D225

Platform:: GPL18573
Series:: GSE100376 GSE100377

Download data: BW

Sample

Accession:: GSM2679757

ID:: 302679757

SRA Run Selector

Select item 3026797567.

Organism:: Homo sapiens

Source name:: monocyte derived dendritic cells infected with HIV in the presence of Vpx, time (hours): 48, drug: none, donor: D225

Platform:: GPL18573
Series:: GSE100376 GSE100377

Download data: BW

Sample

Accession:: GSM2679756

ID:: 302679756

SRA Run Selector

Select item 3026797558.

Organism:: Homo sapiens

Source name:: monocyte derived dendritic cells infected with HIV in the presence of Vpx, time (hours): 32, drug: none, donor: D225

Platform:: GPL18573
Series:: GSE100376 GSE100377

Download data: BW

Sample

Accession:: GSM2679755

ID:: 302679755

SRA Run Selector

Select item 3026797549.

Organism:: Homo sapiens

Source name:: monocyte derived dendritic cells infected with HIV in the presence of Vpx, time (hours): 16, drug: none, donor: D225

Platform:: GPL18573
Series:: GSE100376 GSE100377

Download data: BW

Sample

Accession:: GSM2679754

ID:: 302679754

SRA Run Selector

Select item 30267975310.

Organism:: Homo sapiens

Source name:: monocyte derived dendritic cells infected with HIV in the presence of Vpx, time (hours): 0, drug: none, donor: D225

Platform:: GPL18573
Series:: GSE100376 GSE100377

Download data: BW

Sample

Accession:: GSM2679753

ID:: 302679753

SRA Run Selector

Select item 30267975211.

HIV_RAL_48h_D224

Organism:: Homo sapiens

Source name:: monocyte derived dendritic cells infected with HIV in the presence of Vpx, time (hours): 48, drug: Raltegravir, donor: D224

Platform:: GPL18573
Series:: GSE100376 GSE100377

Download data: BW

Sample

Accession:: GSM2679752

ID:: 302679752

SRA Run Selector

Select item 30267975112.

HIV_RAL_32h_D224

Organism:: Homo sapiens

Source name:: monocyte derived dendritic cells infected with HIV in the presence of Vpx, time (hours): 32, drug: Raltegravir, donor: D224

Platform:: GPL18573
Series:: GSE100376 GSE100377

Download data: BW

Sample

Accession:: GSM2679751

ID:: 302679751

SRA Run Selector

Select item 30267975013.

HIV_RAL_16h_D224

Organism:: Homo sapiens

Source name:: monocyte derived dendritic cells infected with HIV in the presence of Vpx, time (hours): 16, drug: Raltegravir, donor: D224

Platform:: GPL18573
Series:: GSE100376 GSE100377

Download data: BW

Sample

Accession:: GSM2679750

ID:: 302679750

SRA Run Selector

Select item 30267974914.

Organism:: Homo sapiens

Source name:: monocyte derived dendritic cells infected with HIV in the presence of Vpx, time (hours): 0, drug: Raltegravir, donor: D224

Platform:: GPL18573
Series:: GSE100376 GSE100377

Download data: BW

Sample

Accession:: GSM2679749

ID:: 302679749

SRA Run Selector

Select item 30267974815.

Organism:: Homo sapiens

Source name:: monocyte derived dendritic cells infected with HIV in the presence of Vpx, time (hours): 48, drug: none, donor: D224

Platform:: GPL18573
Series:: GSE100376 GSE100377

Download data: BW

Sample

Accession:: GSM2679748

ID:: 302679748

SRA Run Selector

Select item 30267974716.

Organism:: Homo sapiens

Source name:: monocyte derived dendritic cells infected with HIV in the presence of Vpx, time (hours): 32, drug: none, donor: D224

Platform:: GPL18573
Series:: GSE100376 GSE100377

Download data: BW

Sample

Accession:: GSM2679747

ID:: 302679747

SRA Run Selector

Select item 30267974617.

Organism:: Homo sapiens

Source name:: monocyte derived dendritic cells infected with HIV in the presence of Vpx, time (hours): 16, drug: none, donor: D224

Platform:: GPL18573
Series:: GSE100376 GSE100377

Download data: BW

Sample

Accession:: GSM2679746

ID:: 302679746

SRA Run Selector

Select item 30267974518.

Organism:: Homo sapiens

Source name:: monocyte derived dendritic cells infected with HIV in the presence of Vpx, time (hours): 0, drug: none, donor: D224

Platform:: GPL18573
Series:: GSE100376 GSE100377

Download data: BW

Sample

Accession:: GSM2679745

ID:: 302679745

SRA Run Selector

Select item 30267974419.

HIV_RAL_48h_D223

Organism:: Homo sapiens

Source name:: monocyte derived dendritic cells infected with HIV in the presence of Vpx, time (hours): 48, drug: Raltegravir, donor: D223

Platform:: GPL18573
Series:: GSE100376 GSE100377

Download data: BW

Sample

Accession:: GSM2679744

ID:: 302679744

SRA Run Selector

Select item 30267974320.

HIV_RAL_32h_D223

Organism:: Homo sapiens

Source name:: monocyte derived dendritic cells infected with HIV in the presence of Vpx, time (hours): 32, drug: Raltegravir, donor: D223

Platform:: GPL18573
Series:: GSE100376 GSE100377

Download data: BW

Sample

Accession:: GSM2679743

ID:: 302679743

SRA Run Selector

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