GEO DataSets

(Submitter supplied) We addressed the clinical significance and mechanisms behind in vitro cellular responses to ionising radiation (IR)-induced DNA double strand breaks in 74 paediatric ALL patients. We found an apoptosis-resistant response in 36% of patients and an apoptosis-sensitive response in the remaining 64% of leukaemias. Global gene expression profiling of 11 apoptosis-resistant and 11 apoptosis-sensitive ALLs revealed abnormal up-regulation of multiple pro-survival pathways in response to IR in apoptosis-resistant leukaemias and differential post-transcriptional activation of the PI3-Akt pathway was observed in representative resistant cases. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3471

Platform:

GPL96

44 Samples

Download data: CEL

Analysis of B-precursor acute lymphoblastic (ALL) tumor cells exposed to ionizing radiation (IR) to induce DNA damage in vitro. Half of the tumors are sensitive to IR induced apoptosis. Results provide insight into the molecular basis of the differences in response of B-precursor ALL to IR.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 agent, 2 disease state, 22 individual sets

Platform:

GPL96

Series:

GSE13280

44 Samples

Download data: CEL

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 08, 2012: annotation table updated with netaffx build 32 June 24, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site The U133 set includes 2 arrays with a total of 44928 entries and was indexed 29-Jan-2002. more...

Organism:

Homo sapiens

364 DataSets

1125 Series

11 Related Platforms

42430 Samples

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