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Items: 1 to 20 of 26

1.

Genome-wide transcriptomic and translatomic profiling in halofuginone and vehicle treated mouse fibroblasts

(Submitter supplied) Purpose: In mammals, glutamyl-prolyl-tRNA synthetase (EPRS) catalyzes the attachment of two amino acids, glutamic acid (E) and proline (P), to their cognate tRNAs for protein synthesis. We aim to study the mechanism of EPRS in translational regulation of cardiac fibrosis and establish EPRS or its downstream target genes as potential anti-fibrosis therapeutic targets. The goals of this study are to use next generation sequencing (NGS)-derived fibroblast transcriptome profiling (RNA-seq) and translatome profiling (polysome-seq) followed by quantitative reverse transcription polymerase chain reaction (qRT-PCR) methods to identify the downstream effector genes that are preferentially regulated by EPRS at the transcriptional and translational levels. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
24 Samples
Download data: TXT
Series
Accession:
GSE136838
ID:
200136838

PubMed Full text in PMC Similar studies SRA Run Selector

2.

Illumina HiSeq 2500 (Mus musculus)

Organism:
Mus musculus
11128 Series
299563 Samples
Download data
Platform
Accession:
GPL17021
ID:
100017021

3.

HF_Heavy-polysome_replicate-3

Organism:
Mus musculus
Source name:
NIH/3T3 cells treated with 100 nM halofuginone at 37ºC for 24 hrs.
Platform:
GPL17021
Series:
GSE136838
Download data
Sample
Accession:
GSM4059082
ID:
304059082

SRA Run Selector

4.

HF_Heavy-polysome_replicate-2

Organism:
Mus musculus
Source name:
NIH/3T3 cells treated with 100 nM halofuginone at 37ºC for 24 hrs.
Platform:
GPL17021
Series:
GSE136838
Download data
Sample
Accession:
GSM4059081
ID:
304059081

SRA Run Selector

5.

HF_Heavy-polysome_replicate-1

Organism:
Mus musculus
Source name:
NIH/3T3 cells treated with 100 nM halofuginone at 37ºC for 24 hrs.
Platform:
GPL17021
Series:
GSE136838
Download data
Sample
Accession:
GSM4059080
ID:
304059080

SRA Run Selector

6.

HF_Light-polysome_replicate-3

Organism:
Mus musculus
Source name:
NIH/3T3 cells treated with 100 nM halofuginone at 37ºC for 24 hrs.
Platform:
GPL17021
Series:
GSE136838
Download data
Sample
Accession:
GSM4059079
ID:
304059079

SRA Run Selector

7.

HF_Light-polysome_replicate-2

Organism:
Mus musculus
Source name:
NIH/3T3 cells treated with 100 nM halofuginone at 37ºC for 24 hrs.
Platform:
GPL17021
Series:
GSE136838
Download data
Sample
Accession:
GSM4059078
ID:
304059078

SRA Run Selector

8.

HF_Light-polysome_replicate-1

Organism:
Mus musculus
Source name:
NIH/3T3 cells treated with 100 nM halofuginone at 37ºC for 24 hrs.
Platform:
GPL17021
Series:
GSE136838
Download data
Sample
Accession:
GSM4059077
ID:
304059077

SRA Run Selector

9.

HF_Ribosome-free_replicate-3

Organism:
Mus musculus
Source name:
NIH/3T3 cells treated with 100 nM halofuginone at 37ºC for 24 hrs.
Platform:
GPL17021
Series:
GSE136838
Download data
Sample
Accession:
GSM4059076
ID:
304059076

SRA Run Selector

10.

HF_Ribosome-free_replicate-2

Organism:
Mus musculus
Source name:
NIH/3T3 cells treated with 100 nM halofuginone at 37ºC for 24 hrs.
Platform:
GPL17021
Series:
GSE136838
Download data
Sample
Accession:
GSM4059075
ID:
304059075

SRA Run Selector

11.

HF_Ribosome-free_replicate-1

Organism:
Mus musculus
Source name:
NIH/3T3 cells treated with 100 nM halofuginone at 37ºC for 24 hrs.
Platform:
GPL17021
Series:
GSE136838
Download data
Sample
Accession:
GSM4059074
ID:
304059074

SRA Run Selector

12.

HF_Total-RNA_replicate-3

Organism:
Mus musculus
Source name:
NIH/3T3 cells treated with 100 nM halofuginone at 37ºC for 24 hrs.
Platform:
GPL17021
Series:
GSE136838
Download data
Sample
Accession:
GSM4059073
ID:
304059073

SRA Run Selector

13.

HF_Total-RNA_replicate-2

Organism:
Mus musculus
Source name:
NIH/3T3 cells treated with 100 nM halofuginone at 37ºC for 24 hrs.
Platform:
GPL17021
Series:
GSE136838
Download data
Sample
Accession:
GSM4059072
ID:
304059072

SRA Run Selector

14.

HF_Total-RNA_replicate-1

Organism:
Mus musculus
Source name:
NIH/3T3 cells treated with 100 nM halofuginone at 37ºC for 24 hrs.
Platform:
GPL17021
Series:
GSE136838
Download data
Sample
Accession:
GSM4059071
ID:
304059071

SRA Run Selector

15.

Vehicle_Heavy-polysome_replicate-3

Organism:
Mus musculus
Source name:
NIH/3T3 cells treated with 100 nM PBS at 37ºC for 24 hrs.
Platform:
GPL17021
Series:
GSE136838
Download data
Sample
Accession:
GSM4059070
ID:
304059070

SRA Run Selector

16.

Vehicle_Heavy-polysome_replicate-2

Organism:
Mus musculus
Source name:
NIH/3T3 cells treated with 100 nM PBS at 37ºC for 24 hrs.
Platform:
GPL17021
Series:
GSE136838
Download data
Sample
Accession:
GSM4059069
ID:
304059069

SRA Run Selector

17.

Vehicle_Heavy-polysome_replicate-1

Organism:
Mus musculus
Source name:
NIH/3T3 cells treated with 100 nM PBS at 37ºC for 24 hrs.
Platform:
GPL17021
Series:
GSE136838
Download data
Sample
Accession:
GSM4059068
ID:
304059068

SRA Run Selector

18.

Vehicle_Light-polysome_replicate-3

Organism:
Mus musculus
Source name:
NIH/3T3 cells treated with 100 nM PBS at 37ºC for 24 hrs.
Platform:
GPL17021
Series:
GSE136838
Download data
Sample
Accession:
GSM4059067
ID:
304059067

SRA Run Selector

19.

Vehicle_Light-polysome_replicate-2

Organism:
Mus musculus
Source name:
NIH/3T3 cells treated with 100 nM PBS at 37ºC for 24 hrs.
Platform:
GPL17021
Series:
GSE136838
Download data
Sample
Accession:
GSM4059066
ID:
304059066

SRA Run Selector

20.

Vehicle_Light-polysome_replicate-1

Organism:
Mus musculus
Source name:
NIH/3T3 cells treated with 100 nM PBS at 37ºC for 24 hrs.
Platform:
GPL17021
Series:
GSE136838
Download data
Sample
Accession:
GSM4059065
ID:
304059065

SRA Run Selector

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