GSE136931[Accession] - GEO DataSets - NCBI

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Items: 10

Select item 2001369311.

LSH facilitates DNA methylation primarily by promoting UHRF1 DNA accessibility and DNA methylation by DNMT1

(Submitter supplied) Accumulative studies indicate that DNA maintenance methylation by DNMT1 is initiated by binding of UHRF1 to replication fork. However, how UHRF1 gains access to chromatin in S phase is poorly understood. Here we report that LSH, a SNF2 family chromatin remodeler, facilitates DNA methylation in somatic cells primarily by promoting DNA methylation by DNMT1. We show that knockout of LSH in various somatic cells resulted in substantial reduction of DNA methylation, whereas knockout of DNMT3A and DNMT3B only moderately reduced the level of DNA methylation. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Methylation profiling by high throughput sequencing

Platform:: GPL9052
8 Samples

Download data: DIFF, TXT

Series

Accession:: GSE136931

ID:: 200136931

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 1000090522.

Illumina Genome Analyzer (Homo sapiens)

Organism:: Homo sapiens

588 Series
7909 Samples

Platform

Accession:: GPL9052

ID:: 100009052

Select item 3040619593.

Organism:: Homo sapiens

Source name:: HCT116

Platform:: GPL9052
Series:: GSE136931

Download data: TXT

Sample

Accession:: GSM4061959

ID:: 304061959

SRA Run Selector

Select item 3040619584.

HCT116_LSH_KO_RRBS

Organism:: Homo sapiens

Source name:: HCT116

Platform:: GPL9052
Series:: GSE136931

Download data: TXT

Sample

Accession:: GSM4061958

ID:: 304061958

SRA Run Selector

Select item 3040619575.

Organism:: Homo sapiens

Source name:: HeLa

Platform:: GPL9052
Series:: GSE136931

Download data: TXT

Sample

Accession:: GSM4061957

ID:: 304061957

SRA Run Selector

Select item 3040619566.

HeLa_LSH_KO_RRBS

Organism:: Homo sapiens

Source name:: HeLa

Platform:: GPL9052
Series:: GSE136931

Download data: TXT

Sample

Accession:: GSM4061956

ID:: 304061956

SRA Run Selector

Select item 3040619557.

HeLa_LSH_WT_rep2_RNA-seq

Organism:: Homo sapiens

Source name:: HeLa

Platform:: GPL9052
Series:: GSE136931

Sample

Accession:: GSM4061955

ID:: 304061955

SRA Run Selector

Select item 3040619548.

HeLa_LSH_WT_rep1_RNA-seq

Organism:: Homo sapiens

Source name:: HeLa

Platform:: GPL9052
Series:: GSE136931

Sample

Accession:: GSM4061954

ID:: 304061954

SRA Run Selector

Select item 3040619539.

HeLa_LSH_KO_rep2_RNA-seq

Organism:: Homo sapiens

Source name:: HeLa

Platform:: GPL9052
Series:: GSE136931

Sample

Accession:: GSM4061953

ID:: 304061953

SRA Run Selector

Select item 30406195210.

HeLa_LSH_KO_rep1_RNA-seq

Organism:: Homo sapiens

Source name:: HeLa

Platform:: GPL9052
Series:: GSE136931

Sample

Accession:: GSM4061952

ID:: 304061952

SRA Run Selector

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