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Items: 10

1.

HIC2 represses BCL11A transcription to regulate hemoglobin switching during development [CUT&RUN]

(Submitter supplied) The switch from fetal to adult hemoglobin production has been studied in great depth in part because of its relevance to the treatment of hemolobinopathies. Transcription factor BCL11A, which is essential for repression of the fetal beta-type globin (γ-globin) genes after birth, is largely controlled at the level of transcription but the mechanism of BCL11A developmental control is unknown. Here, using a CRISPR-Cas9 screen in human erythroblasts, we identify transcription factor HIC2 as a repressor of BCL11A transcription. more...
Organism:
Homo sapiens
Type:
Other
Platform:
GPL30173
8 Samples
Download data: BED, BIGWIG
Series
Accession:
GSE182530
ID:
200182530

PubMed Full text in PMC Similar studies SRA Run Selector

2.

NextSeq 2000 (Homo sapiens)

Organism:
Homo sapiens
1132 Series
21854 Samples
Download data
Platform
Accession:
GPL30173
ID:
100030173

3.

Adult_GATA1_r2

Organism:
Homo sapiens
Source name:
Adult erythroblasts
Platform:
GPL30173
Series:
GSE173587 GSE182530
Download data: BED, BIGWIG
Sample
Accession:
GSM5530952
ID:
305530952

SRA Run Selector

4.

Adult_GATA1_r1

Organism:
Homo sapiens
Source name:
Adult erythroblasts
Platform:
GPL30173
Series:
GSE173587 GSE182530
Download data: BED, BIGWIG
Sample
Accession:
GSM5530951
ID:
305530951

SRA Run Selector

5.

Fetal_GATA1_r2

Organism:
Homo sapiens
Source name:
Fetal erythroblasts
Platform:
GPL30173
Series:
GSE173587 GSE182530
Download data: BED, BIGWIG
Sample
Accession:
GSM5530950
ID:
305530950

SRA Run Selector

6.

Fetal_GATA1_r1

Organism:
Homo sapiens
Source name:
Fetal erythroblasts
Platform:
GPL30173
Series:
GSE173587 GSE182530
Download data: BED, BIGWIG
Sample
Accession:
GSM5530949
ID:
305530949

SRA Run Selector

7.

Adult_H3K27ac_r2

Organism:
Homo sapiens
Source name:
Adult erythroblasts
Platform:
GPL30173
Series:
GSE173587 GSE182530
Download data: BED, BIGWIG
Sample
Accession:
GSM5530948
ID:
305530948

SRA Run Selector

8.

Adult_H3K27ac_r1

Organism:
Homo sapiens
Source name:
Adult erythroblasts
Platform:
GPL30173
Series:
GSE173587 GSE182530
Download data: BED, BIGWIG
Sample
Accession:
GSM5530947
ID:
305530947

SRA Run Selector

9.

Fetal_H3K27ac_r2

Organism:
Homo sapiens
Source name:
Fetal erythroblasts
Platform:
GPL30173
Series:
GSE173587 GSE182530
Download data: BED, BIGWIG
Sample
Accession:
GSM5530946
ID:
305530946

SRA Run Selector

10.

Fetal_H3K27ac_r1

Organism:
Homo sapiens
Source name:
Fetal erythroblasts
Platform:
GPL30173
Series:
GSE173587 GSE182530
Download data: BED, BIGWIG
Sample
Accession:
GSM5530945
ID:
305530945

SRA Run Selector

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db=gds|term=GSE182530[Accession]|query=1|qty=2|blobid=MCID_674c4978d82608403850766f|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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