GSE210783[Accession] - GEO DataSets - NCBI

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Select item 2002107831.

Precise genomic editing of a pathogenic RBM20 mutation rescues dilated cardiomyopathy

(Submitter supplied) Mutations in RNA binding motif protein 20 (RBM20) are a common cause of dilated cardiomyopathy (DCM). Many RBM20 mutations cluster within an arginine/serine rich (RS-rich) domain, resulting in mis-localization of RBM20 to ribonucleoprotein granules within the cytoplasm, abnormal splicing of cardiac genes, and cardiomyocyte dysfunction. We used adenine base editing (ABE) and prime editing to correct pathogenic p.R634Q and p.R636S mutations in the RS-rich domain in human isogenic induced pluripotent stem cell-derived cardiomyocytes. more...

Organism:: Homo sapiens; Mus musculus

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL21697 GPL21626
28 Samples

Download data: TXT

Series

Accession:: GSE210783

ID:: 200210783

PubMed Full text in PMC Similar studies

Select item 1000216972.

NextSeq 550 (Homo sapiens)

Organism:: Homo sapiens

1502 Series
44637 Samples

Platform

Accession:: GPL21697

ID:: 100021697

Select item 1000216263.

NextSeq 550 (Mus musculus)

Organism:: Mus musculus

1401 Series
59759 Samples

Platform

Accession:: GPL21626

ID:: 100021626

Select item 3064376054.

Corrected [Taka16]

Organism:: Mus musculus

Source name:: Heart

Platform:: GPL21626
Series:: GSE210783

Download data: TXT

Sample

Accession:: GSM6437605

ID:: 306437605

SRA Run Selector

Select item 3064376045.

Corrected [Taka15]

Organism:: Mus musculus

Source name:: Heart

Platform:: GPL21626
Series:: GSE210783

Download data: TXT

Sample

Accession:: GSM6437604

ID:: 306437604

SRA Run Selector

Select item 3064376036.

Corrected [Taka14]

Organism:: Mus musculus

Source name:: Heart

Platform:: GPL21626
Series:: GSE210783

Download data: TXT

Sample

Accession:: GSM6437603

ID:: 306437603

SRA Run Selector

Select item 3064376027.

Corrected [Taka13]

Organism:: Mus musculus

Source name:: Heart

Platform:: GPL21626
Series:: GSE210783

Download data: TXT

Sample

Accession:: GSM6437602

ID:: 306437602

SRA Run Selector

Select item 3064376018.

R636Q_homozygous [Taka12]

Organism:: Mus musculus

Source name:: Heart

Platform:: GPL21626
Series:: GSE210783

Download data: TXT

Sample

Accession:: GSM6437601

ID:: 306437601

SRA Run Selector

Select item 3064376009.

R636Q_homozygous [Taka11]

Organism:: Mus musculus

Source name:: Heart

Platform:: GPL21626
Series:: GSE210783

Download data: TXT

Sample

Accession:: GSM6437600

ID:: 306437600

SRA Run Selector

Select item 30643759910.

R636Q_homozygous [Taka10]

Organism:: Mus musculus

Source name:: Heart

Platform:: GPL21626
Series:: GSE210783

Download data: TXT

Sample

Accession:: GSM6437599

ID:: 306437599

SRA Run Selector

Select item 30643759811.

R636Q_homozygous [Taka9]

Organism:: Mus musculus

Source name:: Heart

Platform:: GPL21626
Series:: GSE210783

Download data: TXT

Sample

Accession:: GSM6437598

ID:: 306437598

SRA Run Selector

Select item 30643759712.

R636Q_heterozygous [Taka8]

Organism:: Mus musculus

Source name:: Heart

Platform:: GPL21626
Series:: GSE210783

Download data: TXT

Sample

Accession:: GSM6437597

ID:: 306437597

SRA Run Selector

Select item 30643759613.

R636Q_heterozygous [Taka7]

Organism:: Mus musculus

Source name:: Heart

Platform:: GPL21626
Series:: GSE210783

Download data: TXT

Sample

Accession:: GSM6437596

ID:: 306437596

SRA Run Selector

Select item 30643759514.

R636Q_heterozygous [Taka6]

Organism:: Mus musculus

Source name:: Heart

Platform:: GPL21626
Series:: GSE210783

Download data: TXT

Sample

Accession:: GSM6437595

ID:: 306437595

SRA Run Selector

Select item 30643759415.

R636Q_heterozygous [Taka5]

Organism:: Mus musculus

Source name:: Heart

Platform:: GPL21626
Series:: GSE210783

Download data: TXT

Sample

Accession:: GSM6437594

ID:: 306437594

SRA Run Selector

Select item 30643759316.

Organism:: Mus musculus

Source name:: Heart

Platform:: GPL21626
Series:: GSE210783

Download data: TXT

Sample

Accession:: GSM6437593

ID:: 306437593

SRA Run Selector

Select item 30643759217.

Organism:: Mus musculus

Source name:: Heart

Platform:: GPL21626
Series:: GSE210783

Download data: TXT

Sample

Accession:: GSM6437592

ID:: 306437592

SRA Run Selector

Select item 30643759118.

Organism:: Mus musculus

Source name:: Heart

Platform:: GPL21626
Series:: GSE210783

Download data: TXT

Sample

Accession:: GSM6437591

ID:: 306437591

SRA Run Selector

Select item 30643759019.

Organism:: Mus musculus

Source name:: Heart

Platform:: GPL21626
Series:: GSE210783

Download data: TXT

Sample

Accession:: GSM6437590

ID:: 306437590

SRA Run Selector

Select item 30643758920.

Corrected [TN15]

Organism:: Homo sapiens

Source name:: iPSC-derived cardiomyocytes

Platform:: GPL21697
Series:: GSE210783

Download data: TXT

Sample

Accession:: GSM6437589

ID:: 306437589

SRA Run Selector

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