GSE235475[Accession] - GEO DataSets - NCBI

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Select item 2002354751.

Trackable Intratumor Microdosing and Spatial Profiling Provide Early Insights into Activity of Investigational Agents in the Intact Tumor Microenvironment

(Submitter supplied) Purpose: Cancer drug development is currently limited by a paradigm of preclinical evaluation that does not adequately recapitulate the complexity of the intact human tumor microenvironment (TME). To overcome this, we combined trackable intratumor microdosing (CIVOTM) with spatial biology readouts to directly assess drug effects in patient tumors in situ. Patients and Methods: In a first-of-its-kind Phase 0 clinical trial, we explored the effects of an investigational stage SUMOylation Activating Enzyme (SAE) inhibitor, subasumstat (TAK-981) in 12 patients with head and neck carcinoma (HNC). more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL32550
354 Samples

Download data: TXT

Series

Accession:: GSE235475

ID:: 200235475

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 1000325502.

Cancer Transcriptomic Atlas, Human, 1812 genes, Nanostring GeoMx Digital Spatial Profiling (DSP) Platform

(Submitter supplied) See manfacturer's website

Organism:: Homo sapiens

2 Series
449 Samples

Platform

Accession:: GPL32550

ID:: 100032550

Select item 3075028243.

Patient 2 Slide A410 ROI 014

Organism:: Homo sapiens

Source name:: head and neck carcinoma

Platform:: GPL32550
Series:: GSE235475

Sample

Accession:: GSM7502824

ID:: 307502824

Select item 3075028234.

Patient 2 Slide A410 ROI 013

Organism:: Homo sapiens

Source name:: head and neck carcinoma

Platform:: GPL32550
Series:: GSE235475

Sample

Accession:: GSM7502823

ID:: 307502823

Select item 3075028225.

Patient 2 Slide A410 ROI 021

Organism:: Homo sapiens

Source name:: head and neck carcinoma

Platform:: GPL32550
Series:: GSE235475

Sample

Accession:: GSM7502822

ID:: 307502822

Select item 3075028216.

Patient 2 Slide A410 ROI 020

Organism:: Homo sapiens

Source name:: head and neck carcinoma

Platform:: GPL32550
Series:: GSE235475

Sample

Accession:: GSM7502821

ID:: 307502821

Select item 3075028207.

Patient 2 Slide A410 ROI 019

Organism:: Homo sapiens

Source name:: head and neck carcinoma

Platform:: GPL32550
Series:: GSE235475

Sample

Accession:: GSM7502820

ID:: 307502820

Select item 3075028198.

Patient 12 Slide D18 ROI 052

Organism:: Homo sapiens

Source name:: head and neck carcinoma

Platform:: GPL32550
Series:: GSE235475

Sample

Accession:: GSM7502819

ID:: 307502819

Select item 3075028189.

Patient 12 Slide D18 ROI 051

Organism:: Homo sapiens

Source name:: head and neck carcinoma

Platform:: GPL32550
Series:: GSE235475

Sample

Accession:: GSM7502818

ID:: 307502818

Select item 30750281710.

Patient 12 Slide D18 ROI 049

Organism:: Homo sapiens

Source name:: head and neck carcinoma

Platform:: GPL32550
Series:: GSE235475

Sample

Accession:: GSM7502817

ID:: 307502817

Select item 30750281611.

Patient 12 Slide D18 ROI 048

Organism:: Homo sapiens

Source name:: head and neck carcinoma

Platform:: GPL32550
Series:: GSE235475

Sample

Accession:: GSM7502816

ID:: 307502816

Select item 30750281512.

Patient 12 Slide D18 ROI 047

Organism:: Homo sapiens

Source name:: head and neck carcinoma

Platform:: GPL32550
Series:: GSE235475

Sample

Accession:: GSM7502815

ID:: 307502815

Select item 30750281413.

Patient 12 Slide D18 ROI 046

Organism:: Homo sapiens

Source name:: head and neck carcinoma

Platform:: GPL32550
Series:: GSE235475

Sample

Accession:: GSM7502814

ID:: 307502814

Select item 30750281314.

Patient 12 Slide D18 ROI 045

Organism:: Homo sapiens

Source name:: head and neck carcinoma

Platform:: GPL32550
Series:: GSE235475

Sample

Accession:: GSM7502813

ID:: 307502813

Select item 30750281215.

Patient 12 Slide D18 ROI 044

Organism:: Homo sapiens

Source name:: head and neck carcinoma

Platform:: GPL32550
Series:: GSE235475

Sample

Accession:: GSM7502812

ID:: 307502812

Select item 30750281116.

Patient 12 Slide D18 ROI 043

Organism:: Homo sapiens

Source name:: head and neck carcinoma

Platform:: GPL32550
Series:: GSE235475

Sample

Accession:: GSM7502811

ID:: 307502811

Select item 30750281017.

Patient 12 Slide D18 ROI 042

Organism:: Homo sapiens

Source name:: head and neck carcinoma

Platform:: GPL32550
Series:: GSE235475

Sample

Accession:: GSM7502810

ID:: 307502810

Select item 30750280918.

Patient 12 Slide D18 ROI 041

Organism:: Homo sapiens

Source name:: head and neck carcinoma

Platform:: GPL32550
Series:: GSE235475

Sample

Accession:: GSM7502809

ID:: 307502809

Select item 30750280819.

Patient 12 Slide D18 ROI 035

Organism:: Homo sapiens

Source name:: head and neck carcinoma

Platform:: GPL32550
Series:: GSE235475

Sample

Accession:: GSM7502808

ID:: 307502808

Select item 30750280720.

Patient 12 Slide D18 ROI 034

Organism:: Homo sapiens

Source name:: head and neck carcinoma

Platform:: GPL32550
Series:: GSE235475

Sample

Accession:: GSM7502807

ID:: 307502807

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