GSE241066[Accession] - GEO DataSets - NCBI

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Items: 11

Select item 2002410661.

USP10-mediated MOF (KAT8) stabilization accelerates the malignant progression of esophageal squamous cell carcinoma via epigenetically activating of ANXA2/Wnt signaling

(Submitter supplied) Dysregulation of MOF (MYST1, KAT8), a highly conserved H4K16 acetyltransferase, plays important roles in human cancers. However, its expression and function in esophageal squamous cell carcinoma (ESCC) remain unknown. Here, we report that MOF is highly expressed in ESCC tumors and predicts a worse prognosis. Depletion of MOF in ESCC significantly impedes tumor growth and metastasis both in vitro and in vivo, whereas ectopic expression of MOF but not enzyme inactive mutant (MOF E350Q) promotes ESCC progression, suggesting that MOF acetyltransferase activity is crucial for its oncogenic activity. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
9 Samples

Download data: XLS

Series

Accession:: GSE241066

ID:: 200241066

PubMed Similar studies Analyze with GEO2R

Select item 1000246762.

Illumina NovaSeq 6000 (Homo sapiens)

Organism:: Homo sapiens

18354 Series
956159 Samples

Platform

Accession:: GPL24676

ID:: 100024676

Select item 3077146683.

Organism:: Homo sapiens

Source name:: esophagus mucosa

Platform:: GPL24676
Series:: GSE241066

Sample

Accession:: GSM7714668

ID:: 307714668

SRA Run Selector

Select item 3077146664.

Organism:: Homo sapiens

Source name:: esophagus mucosa

Platform:: GPL24676
Series:: GSE241066

Sample

Accession:: GSM7714666

ID:: 307714666

SRA Run Selector

Select item 3077146635.

Organism:: Homo sapiens

Source name:: esophagus mucosa

Platform:: GPL24676
Series:: GSE241066

Sample

Accession:: GSM7714663

ID:: 307714663

SRA Run Selector

Select item 3077146616.

Organism:: Homo sapiens

Source name:: esophagus mucosa

Platform:: GPL24676
Series:: GSE241066

Sample

Accession:: GSM7714661

ID:: 307714661

SRA Run Selector

Select item 3077146587.

Organism:: Homo sapiens

Source name:: esophagus mucosa

Platform:: GPL24676
Series:: GSE241066

Sample

Accession:: GSM7714658

ID:: 307714658

SRA Run Selector

Select item 3077146568.

Organism:: Homo sapiens

Source name:: esophagus mucosa

Platform:: GPL24676
Series:: GSE241066

Sample

Accession:: GSM7714656

ID:: 307714656

SRA Run Selector

Select item 3077146539.

Organism:: Homo sapiens

Source name:: esophagus mucosa

Platform:: GPL24676
Series:: GSE241066

Sample

Accession:: GSM7714653

ID:: 307714653

SRA Run Selector

Select item 30771465110.

Organism:: Homo sapiens

Source name:: esophagus mucosa

Platform:: GPL24676
Series:: GSE241066

Sample

Accession:: GSM7714651

ID:: 307714651

SRA Run Selector

Select item 30771464811.

Organism:: Homo sapiens

Source name:: esophagus mucosa

Platform:: GPL24676
Series:: GSE241066

Sample

Accession:: GSM7714648

ID:: 307714648

SRA Run Selector

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