GEO DataSets

(Submitter supplied) Recent work has shown that cytotoxic T cells play a central role in immune-mediated control of cancers1-3, and monoclonal antibodies that target inhibitory receptors on T cells can induce significant clinical benefit in patients despite advanced disease4-6. However, many of the regulatory pathways that result in loss of T cell function within immunosuppressive tumors remain unknown. Here we show that such regulatory mechanisms can be systematically discovered in vivo in the tumor microenvironment. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4986

Platform:

GPL1261

36 Samples

Download data: CEL

Analysis of CD8 T cells that were transduced with shRNAs targeting inhibitors of T-cell function, adoptively transferred into B16 tumor-bearing mice, and purified from spleen or tumor 7 days later. Results provide insight into molecular mechanisms blocking cytotoxic T cell infiltration into tumors.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 6 protocol, 2 tissue sets

Platform:

GPL1261

Series:

GSE53388

36 Samples

Download data: CEL

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 07, 2012: annotation table updated with netaffx build 32 June 23, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site All probe sets represented on the GeneChip Mouse Expression Set 430 are included on the GeneChip Mouse Genome 430 2.0 Array. more...

Organism:

Mus musculus

601 DataSets

4546 Series

40 Related Platforms

58941 Samples

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