GEO DataSets

(Submitter supplied) Responsiveness of cells to alpha-toxin (Hla) from Staphylococcus aureus appears to occur in a cell-type dependent manner. Here, we compare two human bronchial epithelial cell lines, i.e. Hla-susceptible 16HBE14o- and Hla-resistant S9 cells, by a quantitative multi-omics strategy for a better understanding of Hla-induced cellular programs. Phosphoproteomics revealed a substantial impact on phosphorylation-dependent signaling in both cell models and highlights alterations in signaling pathways associated with cell-cell and cell-matrix contacts as well as the actin cytoskeleton as key features of early rHla-induced effects. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS5812

Platform:

GPL6244

8 Samples

Download data: CEL

Analysis of bronchial epithelial cell lines 16HBE14o- (Hla-susceptible) and S9 (Hla-resistant) treated with S. aureus recombinant alpha-toxin (rHla) for 2 hrs. Results provide insight into molecular mechanisms underlying cell type-specific responses of airway epithelial cells to alpha-toxin.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 agent, 2 cell line sets

Platform:

GPL6244

Series:

GSE65018

8 Samples

Download data: CEL

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 18, 2012: annotation table updated with netaffx build 32 July 01, 2016: annotation table updated with netaffx build 35 Protocol: See manufacturer's web site

Organism:

Homo sapiens

136 DataSets

1879 Series

27 Related Platforms

38399 Samples

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