GSE70991[Accession] - GEO DataSets - NCBI

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Select item 2000709911.

Insulator dysfunction and oncogene activation in IDH mutant gliomas

(Submitter supplied) Gain-of-function IDH mutations define major clinical and prognostic classes of gliomas. Mutant IDH protein produces a novel onco-metabolite, 2-hydroxyglutarate (2-HG), that interferes with iron-dependent hydroxylase enzymes, including the TET family of 5'-methylcytosine hydroxylases. TET enzymes are critical for the dynamic regulation of DNA methylation. IDH mutant gliomas thus manifest a CpG island methylator phenotype (G-CIMP), though the functional significance of this altered epigenetic state remains unclear. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL15520 GPL16791 GPL18573
33 Samples

Download data: TDF

Series

Accession:: GSE70991

ID:: 200070991

PubMed Full text in PMC Similar studies

Select item 1000185732.

Illumina NextSeq 500 (Homo sapiens)

Organism:: Homo sapiens

12611 Series
343897 Samples

Platform

Accession:: GPL18573

ID:: 100018573

Select item 1000167913.

Illumina HiSeq 2500 (Homo sapiens)

Organism:: Homo sapiens

12223 Series
349703 Samples

Platform

Accession:: GPL16791

ID:: 100016791

Select item 1000155204.

Illumina MiSeq (Homo sapiens)

Organism:: Homo sapiens

1191 Series
41729 Samples

Platform

Accession:: GPL15520

ID:: 100015520

Select item 3019085835.

Organism:: Homo sapiens

Source name:: BT19m Input

Platform:: GPL18573
Series:: GSE70991

Download data: TDF

Sample

Accession:: GSM1908583

ID:: 301908583

Select item 3019085826.

Organism:: Homo sapiens

Source name:: BT19m CTCF

Platform:: GPL18573
Series:: GSE70991

Download data: TDF

Sample

Accession:: GSM1908582

ID:: 301908582

Select item 3019085817.

Organism:: Homo sapiens

Source name:: BT18m Input

Platform:: GPL18573
Series:: GSE70991

Download data: TDF

Sample

Accession:: GSM1908581

ID:: 301908581

Select item 3019085808.

Organism:: Homo sapiens

Source name:: BT18m CTCF

Platform:: GPL18573
Series:: GSE70991

Download data: TDF

Sample

Accession:: GSM1908580

ID:: 301908580

Select item 3019085799.

Organism:: Homo sapiens

Source name:: BT17m Input

Platform:: GPL18573
Series:: GSE70991

Download data: TDF

Sample

Accession:: GSM1908579

ID:: 301908579

Select item 30190857810.

Organism:: Homo sapiens

Source name:: BT17m CTCF

Platform:: GPL18573
Series:: GSE70991

Download data: TDF

Sample

Accession:: GSM1908578

ID:: 301908578

Select item 30190857711.

Organism:: Homo sapiens

Source name:: BT7w Input

Platform:: GPL18573
Series:: GSE70991

Download data: TDF

Sample

Accession:: GSM1908577

ID:: 301908577

Select item 30190857612.

Organism:: Homo sapiens

Source name:: BT7w CTCF

Platform:: GPL18573
Series:: GSE70991

Download data: TDF

Sample

Accession:: GSM1908576

ID:: 301908576

Select item 30190857513.

Organism:: Homo sapiens

Source name:: BT6w Input

Platform:: GPL18573
Series:: GSE70991

Download data: TDF

Sample

Accession:: GSM1908575

ID:: 301908575

Select item 30190857414.

Organism:: Homo sapiens

Source name:: BT6w CTCF

Platform:: GPL18573
Series:: GSE70991

Download data: TDF

Sample

Accession:: GSM1908574

ID:: 301908574

Select item 30190857315.

Organism:: Homo sapiens

Source name:: BT5w Input

Platform:: GPL18573
Series:: GSE70991

Download data: TDF

Sample

Accession:: GSM1908573

ID:: 301908573

Select item 30190857216.

Organism:: Homo sapiens

Source name:: BT5w CTCF

Platform:: GPL18573
Series:: GSE70991

Download data: TDF

Sample

Accession:: GSM1908572

ID:: 301908572

Select item 30190857117.

Organism:: Homo sapiens

Source name:: BT3w Input

Platform:: GPL18573
Series:: GSE70991

Download data: TDF

Sample

Accession:: GSM1908571

ID:: 301908571

Select item 30190857018.

Organism:: Homo sapiens

Source name:: BT3w CTCF

Platform:: GPL18573
Series:: GSE70991

Download data: TDF

Sample

Accession:: GSM1908570

ID:: 301908570

Select item 30190856919.

Organism:: Homo sapiens

Source name:: BT2w Input

Platform:: GPL18573
Series:: GSE70991

Download data: TDF

Sample

Accession:: GSM1908569

ID:: 301908569

Select item 30190856820.

Organism:: Homo sapiens

Source name:: BT1w Input

Platform:: GPL18573
Series:: GSE70991

Download data: TDF

Sample

Accession:: GSM1908568

ID:: 301908568

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