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Items: 13

1.

OCT4 and SOX2 Work as Transcriptional Activators in Reprogramming Human Fibroblasts

(Submitter supplied) SOX2 and OCT4, in conjunction with KLF4 and cMYC, are sufficient to reprogram human fibroblasts to induced pluripotent stem cells (iPSCs), but it is unclear if they function as transcriptional activators or as repressors. We now show that, like OCT4, SOX2 functions as a transcriptional activator. We substituted SOX2-VP16 (a strong activator) for wild-type (WT) SOX2, and we saw an increase in the efficiency and rate of reprogramming, whereas the SOX2-HP1 fusion (a strong repressor) eliminated reprogramming. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10558
11 Samples
Download data: TXT
Series
Accession:
GSE81891
ID:
200081891
2.

Illumina HumanHT-12 V4.0 expression beadchip

(Submitter supplied) The HumanHT-12 v4 Expression BeadChip provides high throughput processing of 12 samples per BeadChip without the need for expensive, specialized automation. The BeadChip is designed to support flexible usage across a wide-spectrum of experiments. The updated content on the HumanHT-12 v4 Expression BeadChips provides more biologically meaningful results through genome-wide transcriptional coverage of well-characterized genes, gene candidates, and splice variants. more...
Organism:
Homo sapiens
51 DataSets
2946 Series
4 Related Platforms
105286 Samples
Download data: TXT
Platform
Accession:
GPL10558
ID:
100010558
3.

MRC5 fibroblasts, day 5, replicate 1

Organism:
Homo sapiens
Source name:
MRC5 fibroblasts, day 5
Platform:
GPL10558
Series:
GSE81891 GSE81900
Download data
Sample
Accession:
GSM2177042
ID:
302177042
4.

MRC5 fibroblasts, day 5, replicate 2

Organism:
Homo sapiens
Source name:
MRC5 fibroblasts, day 5
Platform:
GPL10558
Series:
GSE81891 GSE81900
Download data
Sample
Accession:
GSM2177041
ID:
302177041
5.

OSKM, day 5, replicate 1

Organism:
Homo sapiens
Source name:
OSKM, day 5
Platform:
GPL10558
Series:
GSE81891 GSE81900
Download data
Sample
Accession:
GSM2177040
ID:
302177040
6.

OSKM, day 5, replicate 2

Organism:
Homo sapiens
Source name:
OSKM, day 5
Platform:
GPL10558
Series:
GSE81891 GSE81900
Download data
Sample
Accession:
GSM2177039
ID:
302177039
7.

OSKM, day 5, replicate 3

Organism:
Homo sapiens
Source name:
OSKM, day 5
Platform:
GPL10558
Series:
GSE81891 GSE81900
Download data
Sample
Accession:
GSM2177038
ID:
302177038
8.

OS(v)KM, day 5, replicate 1

Organism:
Homo sapiens
Source name:
OS(v)KM, day 5
Platform:
GPL10558
Series:
GSE81891 GSE81900
Download data
Sample
Accession:
GSM2177037
ID:
302177037
9.

OS(v)KM, day 5, replicate 2

Organism:
Homo sapiens
Source name:
OS(v)KM, day 5
Platform:
GPL10558
Series:
GSE81891 GSE81900
Download data
Sample
Accession:
GSM2177036
ID:
302177036
10.

OS(v)KM, day 5, replicate 3

Organism:
Homo sapiens
Source name:
OS(v)KM, day 5
Platform:
GPL10558
Series:
GSE81891 GSE81900
Download data
Sample
Accession:
GSM2177035
ID:
302177035
11.

hiPS S1 (on MEFs)

Organism:
Homo sapiens
Source name:
hiPS S1 (on MEFs)
Platform:
GPL10558
Series:
GSE81891 GSE81900
Download data
Sample
Accession:
GSM2177034
ID:
302177034
12.

H1 hESC (Feeder free)

Organism:
Homo sapiens
Source name:
H1 hESC (Feeder free)
Platform:
GPL10558
Series:
GSE81891 GSE81900
Download data
Sample
Accession:
GSM2177033
ID:
302177033
13.

hiPS R4 (Feeder free)

Organism:
Homo sapiens
Source name:
hiPS R4 (Feeder free)
Platform:
GPL10558
Series:
GSE81891 GSE81900
Download data
Sample
Accession:
GSM2177032
ID:
302177032

Supplemental Content

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