GEO DataSets

(Submitter supplied) Monocyte chemoattractant protein 1 (MCP-1/CCL2) is critically involved in directing the migration of blood monocytes to sites of inflammation. Consequently, excessive MCP-1 secretion has been linked to many (auto)inflammatory diseases, whereas a lack of expression severely impairs immune responsiveness. We demonstrate that the atypical inhibitor of NF-κB ζ (IκBζ), a transcriptional co-activator required for the selective expression of a subset of NF-κB target genes, is a key activator of the Ccl2 gene. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4578

Platform:

GPL6246

12 Samples

Download data: CEL

Analysis of IκBζ-deficient peritoneal macrophages (PMψ) stimulated with LPS. These PMψ exhibit impaired secretion of monocyte chemoattractant protein 1 (MCP-1) which is critical for directing monocyte migration to inflammation sites. Results provide insight into role of IκBζ in Mψ physiology.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 genotype/variation, 2 protocol sets

Platform:

GPL6246

Series:

GSE43075

12 Samples

Download data: CEL

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 07, 2012: annotation table updated with netaffx build 32 July 01, 2016: annotation table updated with netaffx build 35 Protocol: See manufacturer's web site

Organism:

Mus musculus

143 DataSets

2504 Series

28 Related Platforms

30419 Samples

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