GSM1064933[Accession] - GEO DataSets

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Items: 4

Select item 2000439001.

Co-ordinate inhibition of autism candidate genes by topoisomerase inhibitors

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens; Mus musculus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by array

5 related Platforms
70 Samples

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Accession:: GSE43900

ID:: 200043900

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000435262.

Co-ordinate inhibition of autism candidate genes by topoisomerase inhibitors [Seq]

(Submitter supplied) Topoisomerases are necessary for the expression of neurodevelopmental genes, and are mutated in some patients with autism spectrum disorder (ASD). We have studied the effects of inhibitors of Topoisomerase 1 (Top1) and Topoisomerase 2 (Top2) enzymes on mouse cortical neurons. We find that topoisomerases selectively inhibit long genes (>100kb), with little effect on all other gene expression. Using ChIPseq against RNA Polymerase II (Pol2) we show that the Top1 inhibitor topotecan blocks transcriptional elongation of long genes specifically. more...