GSM1077163[Accession] - GEO DataSets

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Items: 4

Select item 2000440391.

TET1 is a maintenance DNA demethylase that prevents methylation spreading in adult cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Methylation profiling by high throughput sequencing; Expression profiling by high throughput sequencing; Expression profiling by array

Platforms:: GPL11154 GPL16686 GPL9115
25 Samples

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Accession:: GSE44039

ID:: 200044039

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000440382.

TET1 is a maintenance DNA demethylase that prevents methylation spreading in adult cells [DREAM]

(Submitter supplied) We report that full length TET1 (TET1-FL) overexpression fails to induce global DNA demethylation in HEK293T cells. The preferential binding of TET1-FL to hypomethylated CpG islands (CGIs) through its CXXC domain leads to its inhibited 5-hydroxymethylcytosine (5hmC) production as methylation level increases. TET1-FL-induced 5hmC accumulates at CGI edges, while TET1 knockdown induces methylation spreading from methylated edges into hypomethylated CGIs. more...