GSM1079802[Accession] - GEO DataSets

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Items: 4

Select item 2000441631.

Let-7 represses Nr6a1 and a mid-gestation developmental program in adult fibroblasts

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by array; Other

4 related Platforms
52 Samples

Download data: BED, BW, CEL, TXT

Series

Accession:: GSE44163

ID:: 200044163

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000441592.

Let-7 represses Nr6a1 and a mid-gestation developmental program in adult fibroblasts [ChIP-seq_histone]

(Submitter supplied) MicroRNAs (miRNAs) are critical to proliferation, differentiation, and development. Here, we characterize gene expression in murine Dicer-null adult mesenchymal stem cell lines, a fibroblast cell type. Loss of Dicer leads to de-repression of let-7 targets at levels that exceed 10-100 fold with increases in transcription. Direct and indirect targets of this miRNA belong to a mid-gestation embryonic program that encompasses known oncofetal genes as well as oncogenes not previously associated with an embryonic state. more...