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Items: 4

1.

Dysregulation of Gene Expression in the 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Lesioined Mouse Substantia Nigra

(Submitter supplied) Parkinson's disease pathogenesis proceeds through several phases, culminating in the loss of dopaminergic neurons of the substantia nigra (SN). Although the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model of oxidative SN injury is frequently used to study degeneration of dopaminergic neurons in mice and non-human primates, an understanding of the temporal sequence of molecular events from inhibition of mitochondrial complex 1 to neuronal cell death is limited. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS2053
Platforms:
GPL32 GPL2892
23 Samples
Download data: CEL
Series
Accession:
GSE4788
ID:
200004788
2.
Full record GDS2053

1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned substantia nigra: time course

Analysis of substantia nigrae (SN) injured by treatment with the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine at 1 and 7 days postlesion. Parkinson's disease (PD) culminates in the loss of dopaminergic neurons of the SN. Results provide insight into the pathogenesis of PD.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 agent, 3 time sets
Platform:
GPL32
Series:
GSE4788
12 Samples
Download data: CEL
3.

[MG_U74A] Affymetrix Murine Genome U74A Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 21, 2012: annotation table updated with netaffx build 32 July 06, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site The MG-U74 version 1 set comprises three arrays representing over 36,000 mouse genes and ESTs. more...
Organism:
Mus musculus
14 DataSets
24 Series
302 Samples
Download data
Platform
Accession:
GPL32
ID:
100000032
4.

Substantia Nigra MML Sample3 RMA, MAS 5, dChip

Organism:
Mus musculus
Source name:
Pooled Substantia Nigra C57BL/6 MPTP MML
Platform:
GPL32
Series:
GSE4788
Dataset:
GDS2053
Download data: CEL
Sample
Accession:
GSM108090
ID:
300108090
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db=gds|term=GSM108090[Accession]|query=1|qty=2|blobid=MCID_6748b93c462e1a751e0e2cbd|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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