GEO DataSets

(Submitter supplied) A cardinal symptom of Major Depressive Disorder (MDD) is the disruption of circadian patterns. Yet, to date, there is no direct evidence of circadian clock dysregulation in the brains of MDD patients. Circadian rhythmicity of gene expression has been observed in animals and peripheral human tissues, but its presence and variability in the human brain was difficult to characterize. Here we applied time-of-death analysis to gene expression data from high-quality postmortem brains, examining 24-hour cyclic patterns in six cortical and limbic regions of 55 subjects with no history of psychiatric or neurological illnesses ('Controls') and 34 MDD patients. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL17027

670 Samples

Download data: CEL

(Submitter supplied) Identical to GPL96 but used a custom CDF Protocol: see manufacturer's web site

Organism:

Homo sapiens

2 Series

1 Related Platform

905 Samples

Download data: CDF