GSM1130355[Accession] - GEO DataSets

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Items: 4

Select item 2000464481.

Selective enhancement and repression of glucocorticoid receptor signaling by coregulator Hic-5

(Submitter supplied) The glucocorticoid receptor (GR) recruits many coregulators via the well characterized AF2 interaction surface in the GR ligand binding domain, but LIM domain coregulator Hic-5 binds to the relatively uncharacterized tau2 activation domain in the hinge region of GR. Requirement of Hic-5 for glucocorticoid-regulated gene expression in U2OS osteosarcoma cells was defined by Hic-5 depletion and global gene expression analysis. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS5269
Platform:: GPL10558
48 Samples

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Series

Accession:: GSE46448

ID:: 200046448

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 52692.

Hydrogen peroxide-inducible clone-5 deficiency effect on dexamethasone-treated osteosarcoma cells: time course

Analysis of U2OS-GR osteosarcoma cells (which stably express glucocorticoid receptor α) depleted for hydrogen peroxide-inducible clone-5 (Hic-5) then treated with the GR ligand dexamethasone for up to 24hrs. Results provide insight into the role of LIM domain coregulator Hic-5 in GR signaling.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 2 agent, 3 protocol, 4 time sets

Platform:: GPL10558
Series:: GSE46448
48 Samples

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DataSet

Accession:: GDS5269

ID:: 5269

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 1000105583.

Illumina HumanHT-12 V4.0 expression beadchip

(Submitter supplied) The HumanHT-12 v4 Expression BeadChip provides high throughput processing of 12 samples per BeadChip without the need for expensive, specialized automation. The BeadChip is designed to support flexible usage across a wide-spectrum of experiments. The updated content on the HumanHT-12 v4 Expression BeadChips provides more biologically meaningful results through genome-wide transcriptional coverage of well-characterized genes, gene candidates, and splice variants. more...