GSM1145649[Accession] - GEO DataSets

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Items: 4

Select item 2000471451.

CLK:BMAL1 is a pioneer-like transcription factor

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL13112
101 Samples

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Accession:: GSE47145

ID:: 200047145

PubMed Full text in PMC Similar studies

Select item 2000471422.

CLK:BMAL1 is a pioneer-like transcription factor [MNase-Seq]

(Submitter supplied) The mammalian circadian clock relies on the master genes CLOCK (CLK) and BMAL1 and drives rhythmic gene expression to regulate biological functions under circadian control. We recently uncovered a surprising disconnect between the rhythmic binding of CLK:BMAL1 on DNA and the transcription of its target genes, suggesting that they are regulated by as yet uncharacterized mechanisms. Here we show that rhythmic CLK:BMAL1 DNA binding promotes rhythmic chromatin opening. more...