GEO DataSets

(Submitter supplied) The NS1 protein of influenza A virus (IAV) is a multifunctional virulence factor. Mouse adaptive mutations in the NS1 protein of the human isolate A/Hong Kong/1/1968(H3N2) (HK) have been previously reported to increase virulence, viral fitness, and interferon antagonism, but differ in binding to post-transcriptional processing factor CPSF30. Because nuclear trafficking is a major genetic determinant of influenza virus host adaptation, we assessed subcellular localization and host gene expression of NS1 adaptive mutations. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4996

Platform:

GPL6246

42 Samples

Download data: CEL, CHP

Analysis of M1 cells following infection with H3N2 human influenza isolate A/Hong Kong/1/1968 (HK-wt) or mouse-adapted (MA), recombinant HK NS1 mutants. NS1 protein is a multifunctional virulence factor. Results provide insight into the molecular effects of MA NS1 mutations on host gene expression.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 14 infection sets

Platform:

GPL6246

Series:

GSE48217

42 Samples

Download data: CEL, CHP

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 07, 2012: annotation table updated with netaffx build 32 July 01, 2016: annotation table updated with netaffx build 35 Protocol: See manufacturer's web site

Organism:

Mus musculus

143 DataSets

2504 Series

28 Related Platforms

30419 Samples

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