GEO DataSets

(Submitter supplied) The anti-HIV humoral immune response following acute infection is delayed and ineffective. HIV envelope protein gp120 binds to and signals through α4β7 on T cells. We show that gp120 also binds and signals through α4β7 on B cells, resulting in an abortive proliferative response. In primary B cells, gp120 signaling through α4β7 resulted in increased expression of TGF-β1 and the B cell inhibitory receptor FcRL4. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS4863

Platform:

GPL6244

42 Samples

Download data: CEL

Temporal analysis of B cells isolated from healthy donors in response to activation in the presence of HIV-1 envelope protein gp120 with high (gp120++) or low (gp120-) affinity for integrin α4β7. Results provide insight into mechanisms by which α4β7-gp120 interaction negatively affects B cells.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 6 individual, 4 protocol, 4 time sets

Platform:

GPL6244

Series:

GSE49019

42 Samples

Download data: CEL

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 18, 2012: annotation table updated with netaffx build 32 July 01, 2016: annotation table updated with netaffx build 35 Protocol: See manufacturer's web site

Organism:

Homo sapiens

136 DataSets

1879 Series

27 Related Platforms

38399 Samples

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