GSM1217185[Accession] - GEO DataSets

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Items: 4

Select item 2000502541.

Integration of toxicological end points with molecular measurements in a 28-day rat repeated dose inhalation study with cigarette smoke provides mechanistic understanding of smoke impact

(Submitter supplied) Demonstration of reduced biological effects with a prototypic modified risk tobacco product. Towards a systems toxicology-based risk assessment, we investigated molecular perturbations accompanying histopathological changes in a 28-day rat inhalation study combining transcriptomics with classical histopathology, and demonstrated reduced biological activity of a prototypic modified risk tobacco product (pMRTP) in comparison to the reference research cigarette 3R4F. more...

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Datasets:: GDS5061 GDS5062 GDS5063
Platform:: GPL1355
75 Samples

Download data: CEL

Series

Accession:: GSE50254

ID:: 200050254

Select item 50622.

Conventional cigarette or modified-risk tobacco product smoke effect on lung parenchyma: dose response

Analysis of left lung parenchyma from males that were nose-only exposed for 28 days to smoke from reference cigarette 3R4F at doses up to 23ug nicotine/l or from a modified risk tobacco product (MRTP) at a dose of 23ug nicotine/l. Results provide insight into the reduced biological activity of MRTP.

Organism:: Rattus norvegicus

Type:: Expression profiling by array, transformed count, 3 agent, 4 dose sets

Platform:: GPL1355
Series:: GSE50254
25 Samples

Download data: CEL

DataSet

Accession:: GDS5062

ID:: 5062

Select item 1000013553.

[Rat230_2] Affymetrix Rat Genome 230 2.0 Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 07, 2012: annotation table updated with netaffx build 32 June 27, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site The GeneChip Rat Genome 230 2.0 Array is a powerful tool for toxicology, neurobiology, and other applications using rat as a model organism. more...