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Items: 4

1.

Integration of toxicological end points with molecular measurements in a 28-day rat repeated dose inhalation study with cigarette smoke provides mechanistic understanding of smoke impact

(Submitter supplied) Demonstration of reduced biological effects with a prototypic modified risk tobacco product. Towards a systems toxicology-based risk assessment, we investigated molecular perturbations accompanying histopathological changes in a 28-day rat inhalation study combining transcriptomics with classical histopathology, and demonstrated reduced biological activity of a prototypic modified risk tobacco product (pMRTP) in comparison to the reference research cigarette 3R4F. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Datasets:
GDS5061 GDS5062 GDS5063
Platform:
GPL1355
75 Samples
Download data: CEL
Series
Accession:
GSE50254
ID:
200050254
2.
Full record GDS5062

Conventional cigarette or modified-risk tobacco product smoke effect on lung parenchyma: dose response

Analysis of left lung parenchyma from males that were nose-only exposed for 28 days to smoke from reference cigarette 3R4F at doses up to 23ug nicotine/l or from a modified risk tobacco product (MRTP) at a dose of 23ug nicotine/l. Results provide insight into the reduced biological activity of MRTP.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, transformed count, 3 agent, 4 dose sets
Platform:
GPL1355
Series:
GSE50254
25 Samples
Download data: CEL
DataSet
Accession:
GDS5062
ID:
5062
3.

[Rat230_2] Affymetrix Rat Genome 230 2.0 Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 07, 2012: annotation table updated with netaffx build 32 June 27, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site The GeneChip Rat Genome 230 2.0 Array is a powerful tool for toxicology, neurobiology, and other applications using rat as a model organism. more...
Organism:
Rattus norvegicus
107 DataSets
750 Series
13 Related Platforms
23059 Samples
Download data
Platform
Accession:
GPL1355
ID:
100001355
4.

Parenchyma-high-3R4F 3

Organism:
Rattus norvegicus
Source name:
Parenchyma-high-3R4F
Platform:
GPL1355
Series:
GSE50254
Dataset:
GDS5062
Download data: CEL
Sample
Accession:
GSM1217203
ID:
301217203
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