GEO DataSets

(Submitter supplied) In this dose series pregnant CD-1 (outbred) dams were exposed to methylmercury (MeHg) as monomethylmercuric chloride injected intraperitoneally on 9 d.p.c. Test doses were 10.0 mg/kg and below. This regimen induces symptoms of Fetal Minimata Disease (FMD) in term fetuses. Risks with respect to FMD for the various test doses were 10.0 mg/kg (40% risk), 5.0 mg/kg (20% risk), 2.5 mg/kg (NOAEL), and 1.25 mg/kg (subNOAEL). more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS635

Platform:

GPL560

8 Samples

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Dose response analysis of methylmercury (MeHg) exposure in embryos. Pregnant 9 days post coitum CD-1 dams injected with 10, 5, 2.5, or 1.25 mg/kg MeHg. Embryonic forebrain examined after 3 hours. MeHg induces symptoms of fetal minamata disease (FMD).

Organism:

Mus musculus

Type:

Expression profiling by array, log ratio, 4 dose sets

Platform:

GPL560

Series:

GSE1075

8 Samples

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(Submitter supplied) Developmental Toxicity of the Mouse Embryo (DTME) includes expression data from early embryos at risk for teratogen-induced eye malformations. Early mouse embryos were exposed to various teratogens during neurulation stages with the aim of correlating large-scale changes in gene expression with a generic histopathological biomarker (p53 protein induction) across the critical period during exposure, and with the risk of malformations in term fetuses (the various exposure scenarios produce ~10% risk of malformations in term fetuses averaged across 50 conditions of the experiment). more...

Organism:

Mus musculus

6 DataSets

10 Series

96 Samples

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