GEO DataSets

(Submitter supplied) Aberrant activation of β-catenin is a common event in Acute Myeloid Leukemia (AML), and is recognized as an independent predictor of poor prognosis. Although increased β-catenin signaling in AML has been associated with AML1-ETO and PML-RARα translocation products, and activating mutations in the FLT3 receptor, it remains unclear which mechanisms activate β-catenin in AML more broadly. Here, we describe a novel link between interleukin-3 (IL-3) signaling and the regulation of β-catenin in myeloid transformation and AML. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS4868

Platform:

GPL6244

16 Samples

Download data: CEL

Analysis of mononuclear cells from acute myeloid leukemia patients (AML 1-4) cultured in the presence of interleukin-3 (IL-3) for up to 16hrs. The overexpression of IL-3Rα in AML has been associated with reduced overall survival. Results provide insight into the role of IL-3 signaling in AML.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 agent, 3 genotype/variation, 4 individual, 2 time sets

Platform:

GPL6244

Series:

GSE51402

16 Samples

Download data: CEL

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 18, 2012: annotation table updated with netaffx build 32 July 01, 2016: annotation table updated with netaffx build 35 Protocol: See manufacturer's web site

Organism:

Homo sapiens

136 DataSets

1879 Series

27 Related Platforms

38399 Samples

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