GEO DataSets

(Submitter supplied) We report that ancestral zinc-finger-domain transcriptional regulators, previously reported to control virulence/symbiosis, implement a cell cycle (S→G1) transcriptional switch. To unravel how this G1-phase transcriptional program is reinstated during a primitive cell cycle, we first defined G1-specific promoters in the model bacterium Caulobacter crescentus by comparative ChIP-Seq analysis. We then exploited one such promoter as genetic proxy, to identify two conserved developmental regulator paralogs, MucR1/2, that constitute a quadripartite and homeostatic regulatory module directing the switch from S→G1-phase transcription. more...

Organism:

Caulobacter vibrioides; Sinorhizobium fredii

Type:

Genome binding/occupancy profiling by high throughput sequencing

Platforms:

GPL18007 GPL18006

11 Samples

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