GEO DataSets

(Submitter supplied) To gain a better understanding of the zinc effect on prostate cells, gene expression profiling analyses were conducted using HPR-1 and PC-3 cells treated with or without zinc (1,500 ng/ml) after 24 hrs serum-depletion. Zinc effect on gene expression was evaluated at 1, 3, and 6 hrs of zinc treatment compared to the control, using human genome survey microarray chips. A total of 6,110 identified genes exhibited three expression patterns in response to zinc a threshold of ±2.5 folds: suppressed (3,534 in PC-3; 1,953 in HPR-1), increased (571 in PC-3; 872 in HPR-1), and otherwise altered (16 in PC-3; 13 in HPR-1). more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3095

Platform:

GPL2986

8 Samples

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Analysis of malignant PC-3 and non-malignant HPR-1 prostate cells treated for up to 6 hours with zinc. Zinc exposure induces apoptosis in PC-3 cells, but not in HPR-1 cells. Results provide insight into the molecular mechanisms underlying zinc-induced prostatic cell apoptosis.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 agent, 2 cell line, 4 time sets

Platform:

GPL2986

Series:

GSE5590

8 Samples

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(Submitter supplied) See manufacturer's web site Protocol: See manufacturer's web site

Organism:

Homo sapiens

5 DataSets

45 Series

1761 Samples

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