GSM1305231[Accession] - GEO DataSets

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Items: 4

Select item 2000540001.

NF-kB coordinates rapid, BRD4-dependent remodeling of proinflammatory super-enhancers

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing; Other

Platforms:: GPL16043 GPL11154
36 Samples

Download data: CEL, WIG

Series

Accession:: GSE54000

ID:: 200054000

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000539992.

NF-kB coordinates rapid, BRD4-dependent remodeling of proinflammatory super-enhancers [Affymetrix]

(Submitter supplied) Proinflammatory stimuli rapidly and globally remodel chromatin landscape, thereby enabling transcriptional responses. Yet, the mechanisms coupling chromatin regulators to the master regulatory inflammatory transcription factor NF-kB remain poorly understood. We report in human endothelial cells (ECs) that activated NF-kB binds to enhancers, provoking a rapid, global redistribution of BRD4 preferentially at super-enhancers, large enhancer domains highly bound by chromatin regulators. more...