GEO DataSets

(Submitter supplied) Cyclin-dependent kinase 7 (CDK7) plays a critical role in the general regulation of RNA polymerase II-mediated transcription. However, the absence of selective CDK7 inhibitors has hindered the ability to investigate the consequences of acute and prolonged inhibition of CDK7 under normal and pathological conditions. Here we present the discovery and characterization of the first covalent CDK7 inhibitor, CDK7-IN-1, that has the unprecedented ability to target a unique cysteine residue located outside of the canonical kinase domain, providing an unanticipated means of achieving selectivity for CDK7 amongst the 20 known CDKs. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL16043

79 Samples

Download data: CEL, CHP

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing

Platforms:

GPL11154 GPL9115 GPL16043

92 Samples

Download data: CEL, CHP, WIG

(Submitter supplied) See details from Affymetrix. This is a commercially available chip.

Organism:

Homo sapiens

89 Series

6761 Samples

Download data: CDF, TXT