GEO DataSets

(Submitter supplied) Deeper understanding of antibiotic-induced physiological responses is critical to identifying means for enhancing our current antibiotic arsenal. Bactericidal antibiotics with diverse targets have been hypothesized to kill bacteria, in part, by inducing production of damaging reactive species. This notion has been supported by many groups, but recently challenged. Here we robustly test the hypothesis using biochemical, enzymatic and biophysical assays along with genetic and phenotypic experiments. more...

Organism:

Escherichia coli; Escherichia coli str. K-12 substr. MG1655

Type:

Expression profiling by array

Datasets:

GDS5160 GDS5162 GDS5163

Platform:

GPL3154

27 Samples

Download data: CEL

Analysis of Δfur and wildtype cells treated with the bacterial antibiotic gentamicin and harvested 1 hr post-treatment. Fur is the master regulator of iron metabolism in E. coli. Results provide insight into Fur's influence on the magnitude of stress responses triggered by bactericidal antibiotics.

Organism:

Escherichia coli; Escherichia coli str. K-12 substr. MG1655

Type:

Expression profiling by array, transformed count, 2 agent, 2 genotype/variation sets

Platform:

GPL3154

Series:

GSE56133

12 Samples

Download data: CEL

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html The GeneChip® E. coli Genome 2.0 Array contains probe sets to detect transcripts from the K12 strain of E. coli and three pathogenic strains of E. coli. Using the new E. coli Genome 2.0 Array, researchers can gain a comprehensive view of three pathogenic forms of E. more...

Organism:

Escherichia coli

10 DataSets

182 Series

1564 Samples

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