GSM139662[Accession] - GEO DataSets

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Items: 4

Select item 2000060141.

A Mitochondria-K+ Channel Axis Is Suppressed in Cancer & Its Normalization Promotes Apoptosis and Inhibits Cancer Growth

(Submitter supplied) The unique metabolic profile of most cancers (aerobic glycolysis) might confer apoptosis-resistance and be therapeutically targeted. Compared to normal cells, several human cancers have high mitochondrial membrane potential and low expression of the K+ channel Kv1.5, both contributing to apoptosis-resistance. Dichloroacetate (DCA), an inhibitor of the mitochondrial pyruvate dehydrogenase kinase (PDK), shifts metabolism from glycolysis to glucose oxidation, decreases mitochondrial membrane potential, increases mitochondrial-H2O2 and activates Kv channels in all cancer, but not normal cells; DCA upregulates Kv1.5 by an NFAT1-dependent mechanism. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS2444
Platform:: GPL96
4 Samples

Download data: CEL

Series

Accession:: GSE6014

ID:: 200006014

Select item 24442.

Dichloroacetate effect on cultured lung carcinoma and glioblastoma cells

Analysis of A549 lung carcinoma and M059K glioblastoma cells treated with dichloroacetate (DCA), an inhibitor of the mitochondrial pyruvate dehydrogenase kinase. DCA shifts metabolism from glycolysis to glucose oxidation and decreases mitochondrial membrane potential in cancer cells.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 2 agent, 2 cell type sets

Platform:: GPL96
Series:: GSE6014
4 Samples

Download data: CEL

DataSet

Accession:: GDS2444

ID:: 2444

Select item 1000000963.

[HG-U133A] Affymetrix Human Genome U133A Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 08, 2012: annotation table updated with netaffx build 32 June 24, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site The U133 set includes 2 arrays with a total of 44928 entries and was indexed 29-Jan-2002. more...