GEO DataSets

(Submitter supplied) Human embryonic stem cells (hESC) show great promise for clinical and research applications, but genomic instability hampers the development of their full potential. Here we demonstrate that increased culture density causes medium acidification due to lactic acid accumulation. hESC are able to cope with this, but acquire increased DNA damage associated to DNA replication stress. Also, single-cell genomics analysis reveals a strong correlation of the occurrence of de novo CNVs and culture density after only five days of culture. more...

Organism:

Homo sapiens

Type:

Genome variation profiling by genome tiling array

Platform:

GPL17760

59 Samples

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(Submitter supplied) BAC array-based comparative genomic hybridization Protocol: http://www.cambridgebluegnome.com/products/24sure

Organism:

Homo sapiens

8 Series

392 Samples

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