GSM143876[Accession] - GEO DataSets

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Items: 3

Select item 2000062621.

Genome Position and Gene Amplification

(Submitter supplied) Amplifications, regions of focal high level copy number change, lead to overexpression of oncogenes or drug resistance genes in tumors. Their presence is often associated with poor prognosis; however the use of amplification as a mechanism for overexpression of a particular gene in tumors varies. To investigate the influence of genome position on propensity to amplify, we integrated a mutant form of DHFR into different positions in the human genome, challenged cells with methotrexate and then studied the genomic alterations arising in drug resistant cells. more...

Organism:: Homo sapiens

Type:: Genome variation profiling by genome tiling array

Platform:: GPL4421
95 Samples

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Accession:: GSE6262

ID:: 200006262

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 1000044212.

UCSF HumArray 3.1

(Submitter supplied) The arrays contain 2464 BAC clones printed as triplicate spots and are described in: Snijders AM, Nowak N, Segraves R, et al. Assembly of microarrays for genome-wide measurement of DNA copy number. Nature Genetics 2001; 29:263-264. Protocol: http://cancer.ucsf.edu/array