GSM1543572[Accession] - GEO DataSets

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Items: 4

Select item 2000470851.

Scl specifies hemogenic endothelium and inhibits cardiogenesis via primed enhancers

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing; Expression profiling by array; Methylation profiling by high throughput sequencing

Platforms:: GPL1261 GPL13112
47 Samples

Download data: BW, CEL, GTF

Series

Accession:: GSE47085

ID:: 200047085

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000470822.

Scl specifies hemogenic endothelium and inhibits cardiogenesis via primed enhancers [ChIP-seq]

(Submitter supplied) Scl/Tal1 confers hemogenic competence and prevents cardiomyogenesis in embryonic endothelium. Here we show that Scl both directly activates a broad gene regulatory network required for hematopoietic stem/progenitor cell (HS/PC) development, and represses transcriptional regulators required for cardiogenesis. Cardiac repression occurs during a short developmental window through Scl binding to distant cardiac enhancers that harbor H3K4me1 at this stage. more...