GSM1809196[Accession] - GEO DataSets

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Items: 4

Select item 2000705551.

Single-cell analysis reveals a stem cell program in human metastatic breast cancer cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by RT-PCR

Platform:: GPL20665
1293 Samples

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Accession:: GSE70555

ID:: 200070555

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000705522.

Single-cell analysis reveals a stem cell program in human metastatic breast cancer cells (PDX mice - cancer cells)

(Submitter supplied) Despite major advances in understanding the molecular and genetic basis of cancer, metastasis remains the cause of >90% of cancer-related mortality1. Understanding metastasis initiation and progression is critical to develop new therapeutic strategies to treat and prevent metastatic disease. Prevailing theories hypothesize that metastases are seeded by rare tumor cells with unique properties, which may function like stem cells in their ability to initiate and propagate metastatic tumors.2 3-5 However, the identity of metastasis-initiating cells in human breast cancer remains elusive, and whether metastases are hierarchically organized is unknown.2 Here we show at the single-cell level that early stage metastatic cells possess a distinct stem-like gene expression signature. more...