GSM187377[Accession] - GEO DataSets

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Items: 4

Select item 2000077081.

Suppression of androgen receptor mediated gene expression by a sequence-specific DNA binding polyamide

(Submitter supplied) Androgen Receptor (AR) is essential for the growth and progression of prostate cancer in both hormone-sensitive and hormone-refractory disease. We have designed a sequence-specific DNA binding polyamide (1) that targets the consensus androgen response element (ARE). This polyamide binds the PSA promoter ARE, inhibits androgen-induced expression of PSA and several other AR-regulated genes in cultured prostate cancer cells, and reduces AR occupancy at the PSA promoter and enhancer. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS2782
Platform:: GPL570
14 Samples

Download data: CEL, CHP

Series

Accession:: GSE7708

ID:: 200007708

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 27822.

Androgen response element specific DNA-binding polyamide effect on dihydrotestoterone-stimulated prostate cell line

Analysis of DHT-stimulated LNCaP prostate cells treated with an androgen response (AR) element (ARE) specific DNA binding polyamide. Polyamide designed to target the sequence 5'-WGWWCW-3' and disrupt AR-mediated gene expression. Effects of the synthetic antiandrogen bicalutamide also examined.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 5 agent sets

Platform:: GPL570
Series:: GSE7708
14 Samples

Download data: CEL, CHP

DataSet

Accession:: GDS2782

ID:: 2782

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 1000005703.

[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 06, 2012: annotation table updated with netaffx build 32 June 23, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site Complete coverage of the Human Genome U133 Set plus 6,500 additional genes for analysis of over 47,000 transcripts All probe sets represented on the GeneChip Human Genome U133 Set are identically replicated on the GeneChip Human Genome U133 Plus 2.0 Array. more...