GSM1981418[Accession] - GEO DataSets

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Items: 4

Select item 2000763371.

Novel contribution of acetylated histone variant H2A.Z in activation of neo-enhancers in prostate cancer

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Methylation profiling by high throughput sequencing; Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing

5 related Platforms
50 Samples

Download data: BED, BEDGRAPH, BW, CEL

Series

Accession:: GSE76337

ID:: 200076337

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000763362.

Novel contribution of acetylated histone variant H2A.Z in activation of neo-enhancers in prostate cancer [ChIP-seq]

(Submitter supplied) Acetylation of the histone variant H2A.Z (H2A.Zac) occurs at active promoters and is associated with oncogene activation in prostate cancer, but its role in enhancer function is still poorly understood. Here we show that H2A.Zac containing nucleosomes are commonly redistributed to neo-enhancers in cancer resulting in a concomitant gain of chromatin accessibility and ectopic gene expression. Notably incorporation of acetylated H2A.Z nucleosomes is a pre-requisite for activation of Androgen receptor (AR) associated enhancers. more...