GSM2101772[Accession] - GEO DataSets

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Items: 4

Select item 2000797361.

RBPJ Maintains Brain Tumor Initiating Cells through CDK9-mediated Transcriptional Elongation

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL16791 GPL18573
18 Samples

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Accession:: GSE79736

ID:: 200079736

PubMed Full text in PMC Similar studies

Select item 2000797352.

RNA-seq Profiles in RBPJ Maintains Brain Tumor Initiating Cells through CDK9-mediated Transcriptional Elongation

(Submitter supplied) Glioblastomas coopt stem cell regulatory pathways to maintain brain tumor initiating cells (BTICs), also known as cancer stem cells. Notch signaling has been a molecular target in BTICs, but Notch antagonists have demonstrated limited efficacy in clinical trials. RBPJ is considered a central transcriptional mediator of Notch activity. Here, we report that pharmacologic Notch inhibitors were less effective than targeting RBPJ in suppressing tumor growth. more...