GEO DataSets

(Submitter supplied) Gene silencing is a powerful approach for interrogating gene function and holds promise for therapeutic applications. Here we repurpose the ERV silencing machinery of embryonic stem cells to stably silence genes in somatic cells by epigenetics. This was achieved by transiently expressing combinations of artificial transcriptional repressors that bind to and synergize at the target locus to instruct de novo DNA methylation, thus ensuing long-term memory of the repressive epigenetic state. more...

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing; Methylation profiling by high throughput sequencing

Platform:

GPL16791

18 Samples

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