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Items: 3

1.

MLL-AF4 Spreading Identifies Binding Sites that Are Distinct from Super-Enhancers and that Govern Sensitivity to DOT1L Inhibition in Leukemia.

(Submitter supplied) Understanding the underlying molecular mechanisms of defined cancers is crucial for effective personalized therapies. Translocations of the Mixed Lineage Leukemia (MLL) gene produce fusion proteins such as MLL-AF4 that disrupt epigenetic pathways and cause poor prognosis leukemias. Here we find that MLL-AF4 occupies a subset of unmethylated CG-enriched genes in combination with its cofactors Menin/LEDGF and ENL. more...
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing
Platforms:
GPL16791 GPL11154 GPL18573
59 Samples
Download data: BED, BW, TXT
Series
Accession:
GSE83671
ID:
200083671

PubMed Full text in PMC Similar studies Analyze with GEO2RSRA Run Selector

2.

Illumina HiSeq 2000 (Homo sapiens)

Organism:
Homo sapiens
10560 Series
183756 Samples
Download data
Platform
Accession:
GPL11154
ID:
100011154

3.

KOPN8_MLL_InputDNA

Organism:
Homo sapiens
Source name:
Leukemia cell line (KOPN-8)
Platform:
GPL11154
Series:
GSE83671
Download data
Sample
Accession:
GSM2212256
ID:
302212256

SRA Run Selector

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db=gds|term=GSM2212256[Accession]|query=1|qty=2|blobid=MCID_674c451796d9ad040623915b|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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