GSM2535924[Accession] - GEO DataSets

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Items: 4

Select item 2000965691.

Single cell RNA-seq reveals expansion of IGRP-reactive CD4+ T cells in recent onset type I diabetes

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL15456 GPL16791
449 Samples

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Accession:: GSE96569

ID:: 200096569

PubMed Full text in PMC Similar studies

Select item 2000965682.

Single cell RNA-seq reveals expansion of IGRP-reactive CD4+ T cells in recent onset type I diabetes (single-cell RNA-seq of CD4+ pooled islet antigen-reactive T cells)

(Submitter supplied) Islet-reactive T cells found in peripheral blood of type 1 diabetes (T1D) subjects are thought to be involved in disease pathogenesis, but full understanding of their role is complicated by their presence also in blood of in healthy subjects. To elucidate their role in T1D, we have combined flow cytometry and single cell RNA sequencing (RNA-seq) techniques to link prior antigen exposure, inferred from expanded TCR clonotypes, and functional capacities of islet antigen-reactive CD4+ memory T cells. more...